Elevated mean platelet volume predicts poor prognosis in colorectal cancer

Altered mean platelet volume (MPV) is implicated in several malignancies. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. The purpose of this study was to elucidate the predictive significance of MPV in CRC. The retrospective stu...

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Published inScientific reports Vol. 7; no. 1; p. 10261
Main Authors Li, Na, Yu, Zhiwei, Zhang, Xin, Liu, Tiemin, Sun, Yu-xiang, Wang, Rui-tao, Yu, Kai-jiang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 31.08.2017
Nature Publishing Group
Subjects
631/67/1504/1885/1393
692/53/2422
Aged
Biomarkers
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - blood
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
Follow-Up Studies
Humanities and Social Sciences
Humans
Kaplan-Meier Estimate
Male
Mean Platelet Volume
Medical prognosis
Middle Aged
multidisciplinary
Neoplasm Grading
Neoplasm Staging
Platelet Count
Platelets
Prognosis
Proportional Hazards Models
Regression analysis
ROC Curve
Science
Science (multidisciplinary)
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Summary:Altered mean platelet volume (MPV) is implicated in several malignancies. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. The purpose of this study was to elucidate the predictive significance of MPV in CRC. The retrospective study recruited 509 consecutive CRC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Of the 509 CRC patients, high MPV levels were detected in 150 (29.5%) patients. Elevated MPV was associated with tumor differentiation (p < 0.001). Patients with increased MPV had poor overall survival compared with those with normal level (60.0% vs. 83.6%, log-rank test, p = 0.035). Cox regression analysis showed that MPV was an independent prognostic factor in CRC (HR = 1.452, 95% CI = 1.118–1.884, p = 0.005). In conclusion, MPV is easily available in routine blood test. Elevated MPV might act as a marker of prognosis and therapeutic target for CRC.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-11053-y