Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

• Published in: Nature reviews. Immunology Vol. 23; no. 3; pp. 135 - 136
• Main Authors: Ju, Yi, Carreño, Juan Manuel, Simon, Viviana, Dawson, Kenneth, Krammer, Florian, Kent, Stephen J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2023; Nature Publishing Group
• Subjects: 631/250; 631/250/590/2293; 692/308/575; 692/699; Antibodies; Antibodies, Neutralizing; Biomedical and Life Sciences; Biomedicine; Comment; Coronaviruses; COVID-19; COVID-19 Vaccines; Drug dosages; Humans; Immunology; Infectious diseases; Lipids; Medicine; mRNA; mRNA vaccines; Nanoparticles; Polyethylene glycol; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Vaccines; Vaccines, Synthetic

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies,...