Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies,...

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Published inNature reviews. Immunology Vol. 23; no. 3; pp. 135 - 136
Main Authors Ju, Yi, Carreño, Juan Manuel, Simon, Viviana, Dawson, Kenneth, Krammer, Florian, Kent, Stephen J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.03.2023
Nature Publishing Group
Subjects
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Antibodies
Antibodies, Neutralizing
Biomedical and Life Sciences
Biomedicine
Comment
Coronaviruses
COVID-19
COVID-19 Vaccines
Drug dosages
Humans
Immunology
Infectious diseases
Lipids
Medicine
mRNA
mRNA vaccines
Nanoparticles
Polyethylene glycol
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccines
Vaccines, Synthetic
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Summary:The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.
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ISSN:1474-1733
1474-1741
1474-1741
DOI:10.1038/s41577-022-00825-x