Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies,...

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Published inNature reviews. Immunology Vol. 23; no. 3; pp. 135 - 136
Main Authors Ju, Yi, Carreño, Juan Manuel, Simon, Viviana, Dawson, Kenneth, Krammer, Florian, Kent, Stephen J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.03.2023
Nature Publishing Group
Subjects
631/250
631/250/590/2293
692/308/575
692/699
Antibodies
Antibodies, Neutralizing
Biomedical and Life Sciences
Biomedicine
Comment
Coronaviruses
COVID-19
COVID-19 Vaccines
Drug dosages
Humans
Immunology
Infectious diseases
Lipids
Medicine
mRNA
mRNA vaccines
Nanoparticles
Polyethylene glycol
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccines
Vaccines, Synthetic
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Abstract The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.
AbstractList The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.
The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.
Author Kent, Stephen J.
Carreño, Juan Manuel
Krammer, Florian
Simon, Viviana
Ju, Yi
Dawson, Kenneth
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  givenname: Juan Manuel
  surname: Carreño
  fullname: Carreño, Juan Manuel
  organization: Department of Microbiology, Icahn School of Medicine at Mount Sinai, Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai
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  givenname: Viviana
  orcidid: 0000-0002-6416-5096
  surname: Simon
  fullname: Simon, Viviana
  organization: Department of Microbiology, Icahn School of Medicine at Mount Sinai, Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
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  givenname: Kenneth
  surname: Dawson
  fullname: Dawson, Kenneth
  organization: Centre for BioNano Interactions, School of Chemistry, University College Dublin
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  orcidid: 0000-0003-4121-776X
  surname: Krammer
  fullname: Krammer, Florian
  email: florian.krammer@mssm.edu
  organization: Department of Microbiology, Icahn School of Medicine at Mount Sinai, Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai
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  givenname: Stephen J.
  orcidid: 0000-0002-8539-4891
  surname: Kent
  fullname: Kent, Stephen J.
  email: skent@unimelb.edu.au
  organization: Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University
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Snippet The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific...
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pubmed
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springer
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StartPage 135
SubjectTerms 631/250
631/250/590/2293
692/308/575
692/699
Antibodies
Antibodies, Neutralizing
Biomedical and Life Sciences
Biomedicine
Comment
Coronaviruses
COVID-19
COVID-19 Vaccines
Drug dosages
Humans
Immunology
Infectious diseases
Lipids
Medicine
mRNA
mRNA vaccines
Nanoparticles
Polyethylene glycol
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccines
Vaccines, Synthetic
Title Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines
URI https://link.springer.com/article/10.1038/s41577-022-00825-x
https://www.ncbi.nlm.nih.gov/pubmed/36539526
https://www.proquest.com/docview/2781036777
https://www.proquest.com/docview/2756671601
https://pubmed.ncbi.nlm.nih.gov/PMC9764299
Volume 23
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