Selecting Clinically Relevant Gait Characteristics for Classification of Early Parkinson’s Disease: A Comprehensive Machine Learning Approach

• Published in: Scientific reports Vol. 9; no. 1; pp. 17269 - 12
• Main Authors: Rehman, Rana Zia Ur, Del Din, Silvia, Guan, Yu, Yarnall, Alison J., Shi, Jian Qing, Rochester, Lynn
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.11.2019; Nature Publishing Group
• Subjects: 692/53/2421; 692/699/375/1718; Aged; Aged, 80 and over; Artificial intelligence; Biomarkers; Classification; Decision making; Female; Gait; Gait - physiology; Gait Analysis - methods; Humanities and Social Sciences; Humans; Learning algorithms; Longitudinal Studies; Machine Learning; Male; Middle Aged; Movement disorders; multidisciplinary; Neurodegenerative diseases; Parkinson Disease - classification; Parkinson's disease; Quality of life; Science; Science (multidisciplinary); Sensitivity and Specificity; Support Vector Machine; Walking - physiology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-53656-7

Parkinson’s disease (PD) is the second most common neurodegenerative disease; gait impairments are typical and are associated with increased fall risk and poor quality of life. Gait is potentially a useful biomarker to help discriminate PD at an early stage, however the optimal characteristics and combination are unclear. In this study, we used machine learning (ML) techniques to determine the optimal combination of gait characteristics to discriminate people with PD and healthy controls (HC). 303 participants (119 PD, 184 HC) walked continuously around a circuit for 2-minutes at a self-paced walk. Gait was quantified using an instrumented mat (GAITRite) from which 16 gait characteristics were derived and assessed. Gait characteristics were selected using different ML approaches to determine the optimal method (random forest with information gain and recursive features elimination (RFE) technique with support vector machine (SVM) and logistic regression). Five clinical gait characteristics were identified with RFE-SVM (mean step velocity, mean step length, step length variability, mean step width, and step width variability) that accurately classified PD. Model accuracy for classification of early PD ranged between 73–97% with 63–100% sensitivity and 79–94% specificity. In conclusion, we identified a subset of gait characteristics for accurate early classification of PD. These findings pave the way for a better understanding of the utility of ML techniques to support informed clinical decision-making.