Pre-screening for osteoporosis with calcaneus quantitative ultrasound and dual-energy X-ray absorptiometry bone density

• Published in: Scientific reports Vol. 11; no. 1; p. 15709
• Main Authors: Yen, Chia-Chi, Lin, Wei-Chun, Wang, Tzu-Hao, Chen, Guan-Fan, Chou, Da-Ying, Lin, Dian-Min, Lin, Shu-Yuan, Chan, Min-Ho, Wu, Jia-Ming, Tseng, Chin-Dar, Huang, Yu-Jie, Lee, Tsair-Fwu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647; 631/45/603; 631/57; 639/166; 692/308; Absorptiometry, Photon - methods; Aged; Aged, 80 and over; Bone Density; Calcaneus; Calcaneus - diagnostic imaging; Correlation coefficient; Dual energy X-ray absorptiometry; Female; Hip; Humanities and Social Sciences; Humans; Logistic Models; Male; Mass Screening; Middle Aged; multidisciplinary; Osteoporosis; Osteoporosis - diagnostic imaging; Prognosis; ROC Curve; Science; Science (multidisciplinary); Sensitivity and Specificity; Spine; Taiwan; Ultrasonography - methods; Taiwan
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-95261-7

Calcaneal quantitative ultrasonography (QUS) is a useful prescreening tool for osteoporosis, while the dual-energy X-ray absorptiometry (DXA) is the mainstream in clinical practice. We evaluated the correlation between QUS and DXA in a Taiwanese population. A total of 772 patients were enrolled and demographic data were recorded with the QUS and DXA T-score over the hip and spine. The correlation coefficient of QUS with the DXA-hip was 0.171. For DXA-spine, it was 0.135 overall, 0.237 in females, and 0.255 in males. The logistic regression model using DXA-spine as a dependent variable was established, and the classification table showed 66.2% accuracy. A receiver operating characteristic (ROC) analyses with Youden’s Index revealed the optimal cut-off point of QUS for predicting osteoporosis to be 2.72. This study showed a meaningful correlation between QUS and DXA in a Taiwanese population. Thus, it is important to pre-screen for osteoporosis with calcaneus QUS.