Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis

• Published in: Nutrients Vol. 15; no. 7; p. 1633
• Main Authors: Yefet, Enav, Bar, Liron, Izhaki, Ido, Iskander, Rula, Massalha, Manal, Younis, Johnny S, Nachum, Zohar
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.03.2023; MDPI
• Subjects: bifidobacterium; Birth size; Birth Weight; Blood Glucose - metabolism; Blood sugar; Cholesterol; Clinical trials; Complications and side effects; Control; Diabetes in pregnancy; Diabetes mellitus; Diabetes, Gestational; Diet therapy; Dietary Supplements; Fasting; Female; Fetus; Fetuses; Gestational age; Gestational diabetes; Glucose; Glycemic Control; Growth; Health aspects; Heterogeneity; High density lipoprotein; Humans; Hypoglycemia; Infant, Newborn; Insulin; Insulin Resistance; Insulins; Laboratory testing; lactobacillus; Lifestyles; lipid profile; Lipids; Lipoproteins (very low density); Meta-analysis; Metabolic disorders; Neonates; Parameters; Pregnancy; Prenatal influences; Probiotics; Probiotics - therapeutic use; Software; Systematic review; Triglycerides; Womens health; Israel; lactobacillus; glucose; insulin resistance; bifidobacterium; lipid profile
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15071633

To assess the effects of probiotic supplements on glycemic control and metabolic parameters in women with gestational diabetes mellitus (GDM) by performing a systematic review and meta-analysis of randomized controlled trials. The primary outcome was glycemic control, i.e., serum glucose and insulin levels. Secondary outcomes were maternal weight gain, neonatal birth weight, and lipid parameters. Weighted mean difference (WMD) was used. Cochrane's Q test of heterogeneity and were used to assess heterogeneity. Of the 843 papers retrieved, 14 ( = 854 women) met the inclusion criteria and were analyzed. When compared with placebo, women receiving probiotic supplements had significantly lower mean fasting serum glucose, fasting serum insulin, homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides, total cholesterol, and VLDL levels. Decreased neonatal birth weight was witnessed in supplements containing Lactobacillus acidophilus. Probiotic supplements may improve glycemic control and lipid profile and reduce neonatal birth weight in women with GDM.