The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respi...

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Published inSignal transduction and targeted therapy Vol. 7; no. 1; p. 57
Main Authors Ning, Qin, Wu, Di, Wang, Xiaojing, Xi, Dong, Chen, Tao, Chen, Guang, Wang, Hongwu, Lu, Huiling, Wang, Ming, Zhu, Lin, Hu, Junjian, Liu, Tingting, Ma, Ke, Han, Meifang, Luo, Xiaoping
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LanguageEnglish
Published London Nature Publishing Group UK 23.02.2022
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Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.
AbstractList The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.
ArticleNumber 57
Author Zhu, Lin
Xi, Dong
Chen, Tao
Wu, Di
Ning, Qin
Wang, Ming
Hu, Junjian
Ma, Ke
Luo, Xiaoping
Wang, Hongwu
Chen, Guang
Lu, Huiling
Liu, Tingting
Han, Meifang
Wang, Xiaojing
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  organization: National Medical Center for Major Public Health Events, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35197452$$D View this record in MEDLINE/PubMed
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Snippet The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses...
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
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SubjectTerms 692/699/1785
692/699/255
Acute Kidney Injury - complications
Acute Kidney Injury - drug therapy
Acute Kidney Injury - immunology
Acute Kidney Injury - virology
Anticoagulants - therapeutic use
Antiviral Agents - therapeutic use
Cancer Research
Cell Biology
Clinical Trials as Topic
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - drug therapy
COVID-19 - immunology
COVID-19 - virology
Cytokine Release Syndrome - complications
Cytokine Release Syndrome - drug therapy
Cytokine Release Syndrome - immunology
Cytokine Release Syndrome - virology
Disseminated Intravascular Coagulation - complications
Disseminated Intravascular Coagulation - drug therapy
Disseminated Intravascular Coagulation - immunology
Disseminated Intravascular Coagulation - virology
Endothelial Cells - drug effects
Endothelial Cells - immunology
Endothelial Cells - virology
Humans
Immunity, Innate - drug effects
Immunologic Factors - therapeutic use
Inflammation
Internal Medicine
Lymphopenia - complications
Lymphopenia - drug therapy
Lymphopenia - immunology
Lymphopenia - virology
Medicine
Medicine & Public Health
Myocarditis - complications
Myocarditis - drug therapy
Myocarditis - immunology
Myocarditis - virology
Oncology
Pathogenesis
Pathology
Public health
Pulmonary Embolism - complications
Pulmonary Embolism - drug therapy
Pulmonary Embolism - immunology
Pulmonary Embolism - virology
Renin-Angiotensin System - drug effects
Renin-Angiotensin System - immunology
Respiratory distress syndrome
Respiratory system
Review
Review Article
SARS-CoV-2 - drug effects
SARS-CoV-2 - growth & development
SARS-CoV-2 - pathogenicity
Severe acute respiratory syndrome coronavirus 2
Therapeutic targets
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Title The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
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