Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors

• Published in: Inflammation research Vol. 68; no. 6; pp. 443 - 458
• Main Authors: Korbecki, Jan, Bobiński, Rafał, Dutka, Mieczysław
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2019; Springer Nature B.V
• Subjects: Allergology; Antioxidants; Arachidonic acid; Biomedical and Life Sciences; Biomedicine; Catalase; Deactivation; Dermatology; Fatty acids; Heme; Heme oxygenase (decyclizing); Immunology; Inactivation; Inflammation; Inflammatory response; Neurology; NF-κB protein; Nonsteroidal anti-inflammatory drugs; Nuclear reactions; Nuclear receptors; Oxygenase; Peroxisome proliferator-activated receptors; Pharmacology/Toxicology; Polyunsaturated fatty acids; Prostaglandins; Proteolysis; PTEN protein; Reactive oxygen species; Receptors; Review; Rheumatology; SIRT1 protein; Superoxide dismutase; Transcription factors; Transmitters; Ubiquitination; NF-κB; Inflammation; Cyclooxygenase-2; Peroxisome proliferator-activated receptor; Signaling pathway

The peroxisome proliferator-activated receptor (PPAR) family includes three transcription factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised and nitrated fatty acid derivatives as well as by cyclopentenone prostaglandins (PGA 2 and 15d-PGJ 2 ) during the inflammator...