Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study

• Published in: Nutrients Vol. 15; no. 5; p. 1083
• Main Authors: Tu, Yen-Chieh, Liu, Yi-Hsueh, Chen, Szu-Chia, Su, Ho-Ming
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.02.2023; MDPI
• Subjects: Adult; Alcohol; Blood pressure; Body mass index; Cholesterol; Complications; Complications and side effects; Diabetes; Diuretics; Exercise; Female; follow-up; Follow-Up Studies; Glucose; Gout; Hemoglobin; High density lipoprotein; Humans; Hyperglycemia; Hypertension; Hypertriglyceridemia; Hyperuricemia; Kidney diseases; Low density lipoprotein; Male; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - epidemiology; metabolic syndrome components; Metabolic syndrome X; Middle Aged; Obesity - complications; Older people; Population studies; Regression analysis; Rheumatism; Risk Factors; Taiwan Biobank; Triglycerides; Uric Acid; Womens health; Taiwan; United States > US; metabolic syndrome; follow-up; hyperuricemia; metabolic syndrome components; Taiwan Biobank
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15051083

The prevalence rate of hyperuricemia remains high in Taiwan, at 21.6% in men and 9.57% in women. Both metabolic syndrome (MetS) and hyperuricemia can cause many complications; however, few studies have evaluated the correlation between MetS and hyperuricemia. Therefore, in this observational cohort study, we explored associations between metabolic syndrome (MetS) and its components and new-onset hyperuricemia. Of 27,033 individuals in the Taiwan Biobank who had complete follow-up data, we excluded those with hyperuricemia at baseline ( = 4871), those with gout at baseline ( = 1043), those with no data on baseline uric acid ( = 18), and those with no data on follow-up uric acid ( = 71). The remaining 21,030 participants (mean age 50.8 ± 10.3 years) were enrolled. We found a significant association between new-onset hyperuricemia with MetS and the components of MetS (hypertriglyceridemia, abdominal obesity, low high-density lipoprotein cholesterol, hyperglycemia, and high blood pressure). Furthermore, compared to those without any MetS components, those with one MetS component (OR = 1.816), two MetS components (OR = 2.727), three MetS components (OR = 3.208), four MetS components (OR = 4.256), and five MetS components (OR = 5.282) were significantly associated with new-onset hyperuricemia (all < 0.001). MetS and its five components were associated with new-onset hyperuricemia in the enrolled participants. Further, an increase in the number of MetS components was associated with an increase in the incidence rate of new-onset hyperuricemia.