Stable sol–gel hydroxyapatite coating on zirconia dental implant for improved osseointegration

• Published in: Journal of materials science. Materials in medicine Vol. 32; no. 7; p. 81
• Main Authors: Kim, Jinyoung, Kang, In-Gu, Cheon, Kwang-Hee, Lee, Sungmi, Park, Suhyung, Kim, Hyoun-Ee, Han, Cheol-Min
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2021; Springer Nature B.V
• Subjects: Adhesive strength; Animals; Biocompatibility; Biomaterials; Biomaterials Synthesis and Characterization; Biomedical Engineering and Bioengineering; Biomedical materials; Cell Adhesion; Cell Line; Cell Proliferation; Cell surface; Ceramics; Chemistry and Materials Science; Coated Materials, Biocompatible - chemistry; Coating; Coatings; Composites; Dental Implants; Dental materials; Durapatite - chemistry; Femur - pathology; Glass; High temperature; Hydroxyapatite; In Vitro Techniques; Materials Science; Materials Testing; Mechanical properties; Mice; Microscopy, Electron, Scanning; Natural Materials; Osseointegration; Osteoconduction; Phase Transition; Polymer Sciences; Pressure; Rabbits; Regenerative Medicine/Tissue Engineering; Sintering; Sol-gel processes; Stress, Mechanical; Surface Properties; Surfaces and Interfaces; Temperature; Thin Films; Titanium - chemistry; Zirconia; Zirconium - chemistry; Zirconium dioxide
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-021-06550-6

Aside from being known for its excellent mechanical properties and aesthetic effect, zirconia has recently attracted attention as a new dental implant material. Many studies have focused on hydroxyapatite (HA) coating for obtaining improved biocompatibility, however the coating stability was reduced by a byproduct produced during the high-temperature sintering process. In this study, to overcome this problem, we simply coated the zirconia surface with a sol–gel-derived hydroxyapatite (HA) layer and then sintered it at a varied temperature (<1000 °C). The surface showed a nanoporous structure, and there was no crystalline phase other than HA and zirconia when the sintering temperature was 800 °C. The adhesion strength of the HA layer (>40 MPa) was also appropriate as a dental implant application. In addition, in vitro cell experiments using a preosteoblast cell line revealed that the HA-coated zirconia surface acts as a preferable surface for cell attachment and proliferation than bare zirconia surface. In vivo animal experiments also demonstrated that the osteoconductivity of zirconia were dramatically enhanced by HA coating, which was comparable to that of Ti implant. These results suggest that the sol–gel-based HA-coated zirconia has a great potential for use as a dental implant material.