Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra

• Published in: Experimental & molecular medicine Vol. 42; no. 12; pp. 823 - 832
• Main Authors: Jeong, Hey-Kyeong, Jou, Ilo, Joe, Eun-hye
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2010; Springer Nature B.V; Korean Society for Biochemistry and Molecular Biology; 생화학분자생물학회
• Subjects: Animals; Astrocytes - pathology; Biomedical and Life Sciences; Biomedicine; Cell Death; Encephalitis - chemically induced; Encephalitis - immunology; Encephalitis - pathology; Injections, Intravenous; Lipopolysaccharides - pharmacology; Male; Medical Biochemistry; Microglia - pathology; Molecular Medicine; Neutrophil Infiltration; Original; Rats; Rats, Sprague-Dawley; Stem Cells; Substantia Nigra - immunology; Substantia Nigra - pathology; 생화학; brain inflammation; neuronal damage; systemic inflammation
• ISSN: 1226-3613; 2092-6413; 2092-6413
• DOI: 10.3858/emm.2010.42.12.085

It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated h...