Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra

It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated h...

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Published inExperimental & molecular medicine Vol. 42; no. 12; pp. 823 - 832
Main Authors Jeong, Hey-Kyeong, Jou, Ilo, Joe, Eun-hye
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.12.2010
Springer Nature B.V
Korean Society for Biochemistry and Molecular Biology
생화학분자생물학회
Subjects
Animals
Astrocytes - pathology
Biomedical and Life Sciences
Biomedicine
Cell Death
Encephalitis - chemically induced
Encephalitis - immunology
Encephalitis - pathology
Injections, Intravenous
Lipopolysaccharides - pharmacology
Male
Medical Biochemistry
Microglia - pathology
Molecular Medicine
Neutrophil Infiltration
Original
Rats
Rats, Sprague-Dawley
Stem Cells
Substantia Nigra - immunology
Substantia Nigra - pathology
생화학
brain inflammation
neuronal damage
systemic inflammation
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Summary:It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged as a risk factor for PD. In the present study, we evaluated how systemic inflammation induced by intravenous (iv) lipopolysaccharides (LPS) injection affected brain inflammation and neuronal damage in the rat. Interestingly, almost all brain inflammatory responses, including morphological activation of microglia, neutrophil infiltration, and mRNA/protein expression of inflammatory mediators, appeared within 4-8 h, and subsided within 1-3 days, in the substantia nigra (SN), where dopaminergic neurons are located. More importantly, however, dopaminergic neuronal loss was not detectable for up to 8 d after iv LPS injection. Together, these results indicate that acute induction of systemic inflammation causes brain inflammation, but this is not sufficiently toxic to induce neuronal injury.
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G704-000088.2010.42.12.003
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0620920100420120823
ISSN:1226-3613
2092-6413
2092-6413
DOI:10.3858/emm.2010.42.12.085