Are Proton Pump Inhibitors Contributing in Emerging New Hypertensive Population?

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 16; no. 10; p. 1387
• Main Authors: Tayal, Rohit, Yasmin, Sabina, Chauhan, Samrat, Singh, Thakur Gurjeet, Saini, Monika, Shorog, Eman, Althubyani, Maryam M, Alsaadi, Baiaan H, Aljohani, Fatimah, Alenazi, Maram A, Abutaily, Sarah A, Ansari, Mohammad Yousuf
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.09.2023; MDPI
• Subjects: adverse effects; Blood pressure; Blood vessels; Distribution; Dosage and administration; Drug therapy; endothelial dysfunction; Enzymes; Fractures; Gastroesophageal reflux; Hypertension; hypocalcemia; Infections; Investigations; Ischemia; Kidney diseases; Nitric oxide; Nonsteroidal anti-inflammatory drugs; Pneumonia; Prescription drugs; Proton Pump Inhibitor; Proton pump inhibitors; Protons; Review; Stomach; Testing; Ulcers; India; adverse effects; hypocalcemia; endothelial dysfunction; hypertension; Proton Pump Inhibitor
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph16101387

Balancing the therapeutic advantages of a medicine with its possible risks and side effects is an important part of medical practice and drug regulation. When a drug is designed to treat a particular disease or medical condition ends up causing additional risks or side effects that lead to the development of other serious health problems, it can have detrimental consequences for patients. This article explores the correlation between persistent proton pump inhibitor (PPI) use and hypertension, a common cardiovascular ailment. While PPIs are beneficial in treating various gastrointestinal problems, their availability without a prescription has resulted in self-medication and long-term use without medical monitoring. Recent findings have revealed a link between long-term PPI usage and increased cardiovascular risks, particularly hypertension. This study investigates the intricate mechanisms underlying PPI's effects, focusing on potential pathways contributing to hypertension, such as endothelial dysfunction, disruption of nitric oxide bioavailability, vitamin B deficiency, hypocalcemia, and hypomagnesemia. The discussion explains how long-term PPI use can disrupt normal endothelial function, vascular control, and mineral balance, eventually leading to hypertension. The article emphasizes the significance of using PPIs with caution and ongoing research to better understand the implications of these medications on cardiovascular health.