Intestinal-type adenocarcinoma presenting as a female periurethral mass

Background The periurethral mass in the female is a rare clinical entity and most of the lesions are benign. We present an unusual case of a periurethral mass found to be intestinal-type adenocarcinoma which has not been previously reported in the literature. Case presentation A 58-year-old woman wa...

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Published inBMC urology Vol. 22; no. 1; pp. 1 - 4
Main Authors Zeng, Ting, Liu, Qiang, Zhu, Shuxia, Xu, Ruihua
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 01.08.2022
BioMed Central
BMC
Subjects
Abdomen
Adenocarcinoma
Biopsy
Cancer
Case Report
Case studies
Chemotherapy
Cysts
Decision making
Diagnosis
Intestinal-type adenocarcinoma
Intestine
Laparoscopy
Magnetic resonance imaging
Medical imaging
MLH1 protein
MSH2 protein
MSH6 protein
Oxaliplatin
Periurethral mass
Tomography
Tumor proteins
Tumors
Urethra
Urinary retention
Urology
Vagina
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Summary:Background The periurethral mass in the female is a rare clinical entity and most of the lesions are benign. We present an unusual case of a periurethral mass found to be intestinal-type adenocarcinoma which has not been previously reported in the literature. Case presentation A 58-year-old woman was referred to our hospital with acute urinary retention. She complained of frequency, urgency and progressive obstructive urinary symptoms for the last 3 months. A pelvic magnetic resonance imaging scan showed a soft tissue mass of 5 x 4 cm surrounding the entire urethra. A needle biopsy was done and revealed adenocarcinoma with intestinal-type features. The tumor was removed by a simultaneous laparoscopic abdominal and transperineal approach. The pathological results showed a positive surgical margin and urethra and vagina wall invasion. The neoplastic cells were positive for CK20, CDX-2, CerbB-2, MSH2, MSH6, MLH1, PMS2 and P53. The patient received adjuvant systemic chemotherapy comprising S-1 and oxaliplatin. Follow-up with pelvic MRI 6 months after surgery showed no signs of local recurrence. Conclusions We have reported the first case of the primary periurethral adenocarcinoma of intestinal type. There are currently no standardized protocols for the diagnosis, clinical course, and treatment of this rare tumor. This case study can aid decision-making regarding the diagnosis and treatment of this tumor. Keywords: Periurethral mass, Intestinal-type adenocarcinoma, Case report
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ISSN:1471-2490
1471-2490
DOI:10.1186/s12894-022-01077-6