Antioxidant Nanozymes: Mechanisms, Activity Manipulation, and Applications

Antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase play important roles in the inhibition of oxidative-damage-related pathological diseases. However, natural antioxidant enzymes face some limitations, including low stability, high cost, and less flexibility. Recen...

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Published inMicromachines (Basel) Vol. 14; no. 5; p. 1017
Main Authors Thao, Nguyen Thi My, Do, Hoang Dang Khoa, Nam, Nguyen Nhat, Tran, Nguyen Khoi Song, Dan, Thach Thi, Trinh, Kieu The Loan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 09.05.2023
MDPI
Subjects
antioxidant nanozyme
Antioxidants
By products
Catalase
Cats
Cerium oxides
Decomposition
enzymatic manipulation
Enzymes
Glutathione
glutathione peroxidase
Hydrogen peroxide
Metal-organic frameworks
Metals
Nanomaterials
Nanoparticles
Oxidation
Oxidative stress
Peroxidase
Review
Stability
Superoxide
Superoxide dismutase
antioxidant nanozyme
superoxide dismutase
catalase
enzymatic manipulation
glutathione peroxidase
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Summary:Antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase play important roles in the inhibition of oxidative-damage-related pathological diseases. However, natural antioxidant enzymes face some limitations, including low stability, high cost, and less flexibility. Recently, antioxidant nanozymes have emerged as promising materials to replace natural antioxidant enzymes for their stability, cost savings, and flexible design. The present review firstly discusses the mechanisms of antioxidant nanozymes, focusing on catalase-, superoxide dismutase-, and glutathione peroxidase-like activities. Then, we summarize the main strategies for the manipulation of antioxidant nanozymes based on their size, morphology, composition, surface modification, and modification with a metal-organic framework. Furthermore, the applications of antioxidant nanozymes in medicine and healthcare are also discussed as potential biological applications. In brief, this review provides useful information for the further development of antioxidant nanozymes, offering opportunities to improve current limitations and expand the application of antioxidant nanozymes.
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These authors contributed equally to this work.
ISSN:2072-666X
2072-666X
DOI:10.3390/mi14051017