Review of biosensing with whispering-gallery mode lasers

Lasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular elec...

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Published inLight, science & applications Vol. 10; no. 1; p. 42
Main Authors Toropov, Nikita, Cabello, Gema, Serrano, Mariana P., Gutha, Rithvik R., Rafti, Matías, Vollmer, Frank
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.02.2021
Springer Nature B.V
Nature Publishing Group
Subjects
140/125
142/136
639/624/1075/1083
639/624/1107/510
639/624/1111/55
Applied and Technical Physics
Atomic
Biosensors
Classical and Continuum Physics
Lasers
Molecular
Optical and Plasma Physics
Optical Devices
Optics
Photonics
Physics
Physics and Astronomy
Review
Review Article
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Summary:Lasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro- and nanoprobing of biological samples that can be integrated with WGM lasers.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2047-7538
2095-5545
2047-7538
DOI:10.1038/s41377-021-00471-3