A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat

• Published in: Nature communications Vol. 10; no. 1; p. 1932
• Main Authors: Yu, Lisha, Shang, Xiaoqiang, Chen, Hao, Xiao, Liping, Zhu, Yihan, Fan, Jie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.04.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 147/143; 639/301/54; 639/638/542/970; 64/60; 692/699/578; Animals; Bandages; Bleeding; Blood coagulation; Bonding strength; Cotton; Cotton Fiber - analysis; Cotton fibers; Crystallization; Dressings; Femoral Artery - injuries; Fibers; Hemorrhage; Hemorrhage - pathology; Hemorrhage - therapy; Hemostasis; Hemostasis - drug effects; Hemostatics; Hemostatics - chemistry; Hemostatics - pharmacology; Humanities and Social Sciences; Humans; Leaching; Mice; multidisciplinary; Porosity; Rabbits; Science; Science (multidisciplinary); Single crystals; Skin - injuries; Sonication; Surgical Wound - pathology; Surgical Wound - therapy; Water flow; Wound Healing - drug effects; Zeolites; Zeolites - chemistry; Zeolites - pharmacology
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-019-09849-9

Achieving rapid definitive hemostasis is essential to ensure survival of patients with massive bleeding in pre-hospital care. It is however challenging to develop hemostatic agents or dressings that simultaneously deliver a fast, long-lasting and safe treatment of hemorrhage. Here, we integrate meso-/micro-porosity, blood coagulation and stability into a flexible zeolite-cotton hybrid hemostat. We employ an on-site template-free growth route that tightly binds mesoporous single-crystal chabazite zeolite onto the surface of cotton fibers. This hemostatic material maintains high procoagulant activity after water flow treatment. Chabazite particles are firmly anchored onto the cotton surface with < 1% leaching after 10 min of sonication. The as-synthesized hemostatic device has superior hemostatic performance over most other clay or zeolite-based inorganic hemostats, in terms of higher procoagulant activity, minimized loss of active components and better scalability for practical applications (a hemostatic T-shirt is hereby demonstrated as an example). Zeolites have attracted attention and have been applied as haemostatic agents; however, there are issues associated with released zeolite powder. Here, the authors report on the growth of zeolites on cotton fibres with high stability and haemostatic ability.