Efficacy and safety of pre-gastroscopy commercial carbohydrate-rich whey protein beverage vs. plain water: a randomised controlled trial

• Published in: Scientific reports Vol. 12; no. 1; p. 17355
• Main Authors: Lua, Bee Chen, Md Hashim, Mohd Nizam, Wong, Mung Seong, Lee, Yeong Yeh, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Wan Zain, Wan Zainira, Syed Abd Aziz, Syed Hassan, Yahya, Maya Mazuwin, Wong, Michael Pak-Kai
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.10.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/308/2779; 692/308/2779/777; Adult; Adverse events; Anxiety; Beverages; Carbohydrates; Gastroscopy; Humanities and Social Sciences; Humans; Hunger; Intervention; Male; Middle Aged; multidisciplinary; NCT; NCT03948594; Proteins; Science; Science (multidisciplinary); Thirst; Water; Well being; Whey protein; Whey Proteins
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-22363-1

Clinical benefits and safety of carbohydrate loading pre-gastroscopy remain unclear. We aimed to determine the effects of a commercial carbohydrate-rich whey protein beverage versus plain water given pre-gastroscopy on gastric residual volume and well-being, and to determine adverse events. This was a single centre, single-blinded, parallel-group, sex-stratified randomized controlled trial. Participants were randomized either to carbohydrate-rich whey protein beverage group (Resource ® , Nestle Health Science) or control group (250 ml plain water) given pre-gastroscopy. Gastric contents were aspirated into a suction reservoir bottle to determine the gastric residual volume (GRV). Visual analogue scale (VAS) of well-being (anxiety, hunger, thirst, tiredness, and weakness) was compared before and after the intervention. Adverse events were also evaluated post-intervention. Of 369 screened, 78 participants (36 males, mean age 49 ± 14.3 years) were randomized. Compared with the control group, carbohydrate beverage was associated with significantly higher GRV (p < 0.001). Anxiety was less after intervention with carbohydrate beverage (p = 0.016), and after adjustment for confounders, fewer participants also experienced hunger (p = 0.043) and thirst (p = 0.021). No serious adverse events were reported with both interventions. Commercial carbohydrate-rich whey protein beverage is associated with higher gastric residual volume, better well-being and safe. Trial registration Clinicaltrial.gov. Identifier: NCT03948594, Date of registration: 14/05/2019.