A comprehensive evaluation of early potential risk factors for disease aggravation in patients with COVID-19

The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more co...

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Published inScientific reports Vol. 11; no. 1; p. 8062
Main Authors Tang, Qiang, Liu, Yanwei, Fu, Yingfeng, Di, Ziyang, Xu, Kailiang, Tang, Bo, Wu, Hui, Di, Maojun
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.04.2021
Nature Publishing Group
Nature Portfolio
Subjects
631/326
692/499
Adolescent
Adult
Aged
Child
Comorbidity
Coronaviruses
COVID-19
COVID-19 - mortality
COVID-19 - pathology
COVID-19 - virology
Diabetes mellitus
Dyspnea
Female
Ferritin
Humanities and Social Sciences
Humans
Hypertension
Intensive Care Units
Interleukin 6
Kaplan-Meier Estimate
Lymphopenia
Male
Medical prognosis
Middle Aged
multidisciplinary
Neutrophilia
Patients
Prognosis
Regression Analysis
Respiration
Retrospective Studies
Risk Factors
SARS-CoV-2 - isolation & purification
Science
Science (multidisciplinary)
Thorax
Tomography, X-Ray Computed
Young Adult
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Summary:The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that advanced age, comorbidities, dyspnea, lymphopenia, and elevated levels of Fbg, CTnI, IL-6, and serum ferritin were significant predictors of disease aggravation. Further, we performed a Kaplan–Meier analysis to evaluate the prognosis of COVID-19 patients, which suggested that 64.9% of the patients had not experienced ICU transfers and survival from the hospital.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-87413-6