Lipid Profiling Reveals Lipidomic Signatures of Weight Loss Interventions

• Published in: Nutrients Vol. 15; no. 7; p. 1784
• Main Authors: Lin, Kaiqing, Cheng, Wei, Shen, Qiwei, Wang, Hui, Wang, Ruwen, Guo, Shanshan, Wu, Xianmin, Wu, Wei, Chen, Peijie, Wang, Yongfei, Ye, Hongying, Zhang, Qiongyue, Wang, Ru
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2023; MDPI
• Subjects: Adrenalectomy; Adrenocorticotropic hormone; Biomarkers; Body weight loss; Care and treatment; Cholesterol; Chromatography, Liquid; Comparative analysis; cushing; Diabetes; Diglycerides; Discriminant analysis; Epidemics; Exercise; Gastrectomy; Gastrointestinal surgery; Health aspects; Hemoglobin; Homeostasis; Humans; Identification and classification; Intervention; laparoscopic sleeve gastrectomy; Laparoscopy; Lecithin; Lipidomics; Lipids; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Measurement; Medical ethics; Metabolism; Methods; Nervous system diseases; Obesity; Overweight; Phosphatidylcholine; Phosphatidylcholines; Phosphatidylethanolamine; Phosphatidylinositol; Phosphatidylserine; Physiological aspects; Pituitary; Plasma; Regression analysis; Signal transduction; Software; Sphingomyelin; Statistical analysis; Surgery; Tandem Mass Spectrometry; Triglycerides; Tumors; Weight control; Weight Loss; China; exercise; laparoscopic sleeve gastrectomy; cushing; lipidomics
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15071784

Obesity is an epidemic all around the world. Weight loss interventions that are effective differ from each other with regard to various lipidomic responses. Here, we aimed to find lipidomic biomarkers that are related to beneficial changes in weight loss. We adopted an untargeted liquid chromatography with tandem mass spectrometry (LC-MS/MS) method to measure 953 lipid species for Exercise (exercise intervention cohort, N = 25), 1388 lipid species for LSG (laparoscopic sleeve gastrectomy cohort, N = 36), and 886 lipid species for Cushing (surgical removal of the ACTH-secreting pituitary adenomas cohort, N = 25). Overall, the total diacylglycerol (DG), triacylglycerol (TG), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), and sphingomyelin (SM) levels were associated with changes in BMI, glycated hemoglobin (HbA1c), triglyceride, and total cholesterol according to weight loss interventions. We found that 73 lipid species changed among the three weight loss interventions. We screened 13 lipid species with better predictive accuracy in diagnosing weight loss situations in either Exercise, LSG, or Cushing cohorts (AUROC > 0.7). More importantly, we identified three phosphatidylcholine (PC) lipid species, PC (14:0_18:3), PC (31:1), and PC (32:2) that were significantly associated with weight change in three studies. Our results highlight potential lipidomic biomarkers that, in the future, could be used in personalized approaches involving weight loss interventions.