Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia

• Published in: Communications biology Vol. 5; no. 1; pp. 396 - 15
• Main Authors: Wang, Zhiqiang, Zhang, Chunxiao, Warden, Charles David, Liu, Zheng, Yuan, Yate-Ching, Guo, Chao, Wang, Charles, Wang, Jinhui, Wu, Xiwei, Ermel, Richard, Vonderfecht, Steven L., Wang, Xiuli, Brown, Christine, Forman, Stephen, Yang, Yaling, James You, M., Chen, WenYong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.04.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/100; 13/109; 13/2; 13/31; 13/89; 14/63; 38/77; 42/41; 45/22; 45/29; 45/90; 631/532/2118/1542; 631/532/7; 692/4028/67/1990/283/1897; 82/29; Aging; Aging - genetics; Animals; Biology; Biomedical and Life Sciences; Bone marrow; Bone marrow transplantation; Genotype & phenotype; Hematological diseases; Hematopoietic stem cells; Hematopoietic Stem Cells - metabolism; Leukemia; Leukemia - genetics; Leukemia - metabolism; Life Sciences; Mice; Oxidative metabolism; Phenotype; Phenotypes; Protein biosynthesis; Protein turnover; SIRT1 protein; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Stem cell transplantation; Stem cells; Therapeutic targets; Transcription factors

Aging of hematopoietic stem cells (HSCs) is linked to various blood disorders and malignancies. SIRT1 has been implicated in healthy aging, but its role in HSC aging is poorly understood. Surprisingly, we found that Sirt1 knockout improved the maintenance of quiescence of aging HSCs and their functi...