Accuracy of shear wave elastography for the diagnosis of prostate cancer: A meta-analysis

Many studies have established the high diagnostic accuracy of shear wave elastography (SWE) for the detection of prostate cancer (PCa); however, its utility remains a subject of debate. This meta-analysis sought to appraise the overall accuracy of SWE for the detection of PCa. A literature search of...

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Bibliographic Details
Published inScientific reports Vol. 7; no. 1; pp. 1949 - 8
Main Authors Sang, Liang, Wang, Xue-mei, Xu, Dong-yang, Cai, Yun-fei
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 16.05.2017
Nature Publishing Group
Nature Portfolio
Subjects
631/67/2321
692/4025/1752
692/699/2768/1753
Accuracy
Aged
Aged, 80 and over
Bayes Theorem
Diagnosis
Elasticity Imaging Techniques
Histopathology
Humanities and Social Sciences
Humans
Male
Meta-analysis
multidisciplinary
Odds Ratio
Prostate cancer
Prostatic Neoplasms - diagnosis
Publication Bias
Reproducibility of Results
ROC Curve
Science
Science (multidisciplinary)
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Summary:Many studies have established the high diagnostic accuracy of shear wave elastography (SWE) for the detection of prostate cancer (PCa); however, its utility remains a subject of debate. This meta-analysis sought to appraise the overall accuracy of SWE for the detection of PCa. A literature search of the PubMed, Embase, Cochrane Library, Web of Science and CNKI (China National Knowledge Infrastructure) databases was conducted. In all of the included studies, the diagnostic accuracy of SWE was compared with that of histopathology, which was used as a standard. Data were pooled, and the sensitivity, specificity, area under the curve (AUC), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated to estimate the accuracy of SWE. The pooled sensitivity and specificity for the diagnosis of PCa by SWE were 0.844 (95% confidence interval: 0.696–0.927) and 0.860 (0.792–0.908), respectively. The AUC was 0.91 (0.89–0.94), the PLR was 6.017 (3.674–9.853), and the NLR was 0.182 (0.085–0.389). The DOR was 33.069 (10.222–106.982). Thus, SWE exhibited high accuracy for the detection of PCa using histopathology as a diagnostic standard. Moreover, SWE may reduce the number of core biopsies needed.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-02187-0