A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors

• Published in: Scientific reports Vol. 12; no. 1; p. 18807
• Main Authors: Li, Ruiqi, Mei, Shuchong, Ding, Qiang, Wang, Qingming, Yu, Li, Zi, Fuming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/129; 631/67/395; Adenocarcinoma; Brain tumors; Breast cancer; Breast Neoplasms - genetics; Cell Line, Tumor; Colorectal cancer; Correlation analysis; Datasets; Female; Fibroblasts; Gene expression; Genomes; Glioma; Head and neck carcinoma; Head and Neck Neoplasms; Helper cells; Hematology; Hexokinase; Hexokinase - genetics; Hexokinase - metabolism; Humanities and Social Sciences; Humans; Invasiveness; Medical prognosis; Melanoma; Metabolism; Metastases; multidisciplinary; Mutation; Ovarian cancer; Papillomavirus Infections; Protein expression; Proteins; Science; Science (multidisciplinary); Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck; Survival analysis; Tumors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-23598-8

More and more evidence show that HK2 is closely related to tumors. But no pan-cancer analysis is available. This paper aimed to explore the potential roles of HK2 across thirty-three tumors based on the datasets of the cancer genome Atlas (TCGA) and gene expression omnibus. HK2 is highly expressed in most tumors and related to the progression of some tumors. HK2 expression was associated with the infiltration of T follicular helper cells for the TCGA tumors of uveal melanoma, breast invasive carcinoma (BRCA), breast invasive carcinoma-luminalA (BRCA-LumA), head and neck squamous cell carcinoma (HNSC), head and neck squamous cell carcinoma with HPV positive (HNSC-HPV + ), and cancer-associated fibroblasts for the tumors of brain lower grade glioma and stomach adenocarcinoma. Our first pan-cancer study offers a relatively comprehensive understanding of the roles of HK2 in different tumors.