Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications
Nanotechnology is one of the most important and relevant disciplines today due to the specific electrical, optical, magnetic, chemical, mechanical and biomedical properties of nanoparticles. In the present study we demonstrate the efficacy of Cuphea procumbens to biogenerate silver nanoparticles (Ag...
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Published in | Scientific reports Vol. 13; no. 1; pp. 790 - 11 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
16.01.2023
Nature Publishing Group Nature Portfolio |
Subjects | |
Online Access | Get full text |
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Summary: | Nanotechnology is one of the most important and relevant disciplines today due to the specific electrical, optical, magnetic, chemical, mechanical and biomedical properties of nanoparticles. In the present study we demonstrate the efficacy of
Cuphea procumbens
to biogenerate silver nanoparticles (AgNPs) with antibacterial and antitumor activity. These nanoparticles were synthesized using the aqueous extract of
C. procumbens
as reducing agent and silver nitrate as oxidizing agent. The Transmission Electron Microscopy demonstrated that the biogenic AgNPs were predominantly quasi-spherical with an average particle size of 23.45 nm. The surface plasmonic resonance was analyzed by ultraviolet visible spectroscopy (UV–Vis) observing a maximum absorption band at 441 nm and Infrared Spectroscopy (FT IR) was used in order to structurally identify the functional groups of some compounds involved in the formation of nanoparticles. The AgNPs demonstrated to have antibacterial activity against the pathogenic bacteria
Escherichia coli
and
Staphylococcus aureus
, identifying the maximum zone of inhibition at the concentration of 0.225 and 0.158 µg/mL respectively. Moreover, compared to the extract, AgNPs exhibited better antitumor activity and higher therapeutic index (TI) against several tumor cell lines such as human breast carcinoma MCF-7 (IC
50
of 2.56 µg/mL, TI of 27.65 µg/mL), MDA-MB-468 (IC
50
of 2.25 µg/mL, TI of 31.53 µg/mL), human colon carcinoma HCT-116 (IC
50
of 1.38 µg/mL, TI of 51.07 µg/mL) and melanoma A-375 (IC
50
of 6.51 µg/mL, TI of 10.89 µg/mL). This fact is of great since it will reduce the side effects derived from the treatment. In addition, AgNPs revealed to have a photocatalytic activity of the dyes congo red (10
–3
M) in 5 min and malachite green (10
–3
M) in 7 min. Additionally, the degradation percentages were obtained, which were 86.61% for congo red and 82.11% for malachite green. Overall, our results demonstrated for the first time that
C. procumbens
biogenerated nanoparticles are excellent candidates for several biomedical and environmental applications. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-022-26818-3 |