Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infection

• Published in: Scientific reports Vol. 11; no. 1; p. 8610
• Main Authors: Ferreiro, Jose Luis Lamas, Otero, Judith Álvarez, Rivo, Ana Sanjurjo, González, Lucía González, Conde, Irene Rodríguez, Soneira, María Fernández, García, Javier Posada, de la Fuente Aguado, Javier
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/107; 631/326/22/1290; Economic impact; Elastomers; Humanities and Social Sciences; Infections; Mortality; multidisciplinary; Observational studies; Patients; Piperacillin; Piperacillin-tazobactam; Pseudomonas aeruginosa; Pumps; Science; Science (multidisciplinary); Tazobactam
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-88179-7

The aim of this study was to evaluate the efficacy and safety of outpatient antimicrobial therapy with piperacillin-tazobactam in continuous infusion using elastomeric pumps and to evaluate the economic impact compared with conventional hospital treatment in patients with Pseudomonas aeruginosa (PA) infections. This is an observational study. Patients with PA infection treated with continuous piperacillin-tazobactam infusion using elastomeric pumps in our hospital between January 2015 and December 2017 were included. Primary outcomes were mortality during antibiotic treatment and mortality at 30 days. Secondary outcomes were reinfection or relapse at 30 days and clinical cure rate. The cost of each episode was compared with theoretical cost of the same treatment using conventional hospitalization. 35 patients were included. One patient (2.9%) died during the treatment. Overall 30-day mortality was 5.7%. No death was related to infection by PA. One patient (2.9%) had a reinfection at 30 days. Cure was achieved in 93% of patients at the end of treatment. There were no severe complications related to elastomeric pumps. Treatment cost with outpatient antimicrobial therapy was 67% lower than theoretical cost with conventional hospital treatment. Oupatient antimicrobial therapy with piperacillin-tazobactam in continuous infusion using elastomeric pumps in patients with PA infections is safe and effective with lower costs.