Hyperuricemia is associated with cardiovascular diseases clustering among very elderly women - a community based study in Chengdu, China

• Published in: Scientific reports Vol. 7; no. 1; pp. 996 - 8
• Main Authors: Huang, Gang, Xu, Jun-bo, Zhang, Ting-jie, Nie, Xiao-li, Li, Qiu, liu, Ya, Lv, Yan, Wen, Rui-lian, Yang, Lei, Zhao, Bao-yu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.04.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4019; 692/499; 692/700/478/174; Biochemical analysis; Cardiovascular diseases; Diabetes; Diabetes mellitus; Dyslipidemia; Geriatrics; Humanities and Social Sciences; Hyperuricemia; multidisciplinary; Obesity; Older people; Renal function; Risk factors; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-01042-6

Cardiovascular epidemiological features among very elderly Chinese are still uncertain. This study aimed to describe the distribution of cardiovascular diseases and sex difference, and investigate potential risk factors for diseases clustering among very elderly Chinese. From May 2013 to May 2015, a total of 1056 very elderly were sampled in this cross-sectional study. Demographic characteristics collection, physical examination and biochemical analysis were performed. Totally, 1038 participants (men: 49.8%) with a median age of 83.0 years (age range: 80.0–100.0 years) were included. In this very elderly group, the prevalences of hypertension, diabetes mellitus, renal dysfunction, hyperuricemia, obesity, visceral obesity, and hypercholesterolaemia were 76.9%, 20.0%, 23.3%, 33.0%, 9.4%, 54.5% and 35.8%, respectively. About 17.5% of very elderly (men vs. women: 15.1% vs 19.8%, p  = 0.007) have ≥3 cardiovascular diseases clustering. Logistic analysis found that hyperuricemia (odds ratio 3.850, 95%CI 2.189–6.770) was associated with of cardiovascular diseases clustering among very elderly women. Prevalences of prehypertension, hyperuricemia, visceral obesity and dyslipidaemia are apparent in very elderly women, while diabetes mellitus, renal dysfunction are common in very elderly men. Women are more likely to have ≥3 cardiovascular diseases. Hyperuricemia is associated with cardiovascular diseases clustering among very elderly women.