Rapid resetting of human peripheral clocks by phototherapy during simulated night shift work
A majority of night shift workers have their circadian rhythms misaligned to their atypical schedule. While bright light exposure at night is known to reset the human central circadian clock, the behavior of peripheral clocks under conditions of shift work is more elusive. The aim of the present stu...
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Published in | Scientific reports Vol. 7; no. 1; pp. 16310 - 11 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
24.11.2017
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | A majority of night shift workers have their circadian rhythms misaligned to their atypical schedule. While bright light exposure at night is known to reset the human central circadian clock, the behavior of peripheral clocks under conditions of shift work is more elusive. The aim of the present study was to quantify the resetting effects of bright light exposure on both central (plasma cortisol and melatonin) and peripheral clocks markers (clock gene expression in peripheral blood mononuclear cells, PBMCs) in subjects living at night. Eighteen healthy subjects were enrolled to either a control (dim light) or a bright light group. Blood was sampled at baseline and on the 4
th
day of simulated night shift. In response to a night-oriented schedule, the phase of
PER1
and
BMAL1
rhythms in PBMCs was delayed by ~2.5–3 h (
P
<
0.05
), while no shift was observed for the other clock genes and the central markers. Three cycles of 8-h bright light induced significant phase delays (
P
< 0.05) of ~7–9 h for central and peripheral markers, except
BMAL1
(advanced by +5h29;
P
<
0.05
). Here, we demonstrate in humans a lack of peripheral clock adaptation under a night-oriented schedule and a rapid resetting effect of nocturnal bright light exposure on peripheral clocks. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-017-16429-8 |