Correction of Negative Effect of Antenatal Hypoxia on Liver Tissue Homeostasis in Newborn Albino Rats with Opioid Peptides

• Published in: Bulletin of experimental biology and medicine Vol. 162; no. 2; pp. 203 - 206
• Main Authors: Pinaeva, O. G., Sazonova, E. N., Lebed’ko, O. A., Timoshin, S. S.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2016; Springer; Springer Nature B.V
• Subjects: Albinism; Animals; Animals, Newborn; Antioxidants (Nutrients); Antioxidants - pharmacology; Biomedical and Life Sciences; Biomedicine; Body Weight - drug effects; Cell Biology; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Cell Nucleus - ultrastructure; Endogenous opioids; Enkephalin (leucine); Enkephalin, Leucine-2-Alanine - analogs & derivatives; Enkephalin, Leucine-2-Alanine - pharmacology; Enkephalins; Female; Free Radicals - antagonists & inhibitors; Hepatocytes; Hepatocytes - drug effects; Hepatocytes - metabolism; Hepatocytes - pathology; Homeostasis; Homeostasis - drug effects; Hypoxia; Hypoxia - drug therapy; Hypoxia - metabolism; Hypoxia - pathology; Internal Medicine; Laboratory Medicine; Liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Narcotics; Nucleoli; Opioid Peptides - pharmacology; Opioid receptors (type mu); Organ Size - drug effects; Oxidation; Oxidative Stress - drug effects; Pathology; Peptides; Peroxidation; Rats; Rats, Wistar; Rodents; DNA synthesis; antenatal hypoxia; opioid peptides; hepatocytes; free radical oxidation
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-016-3576-y

We studied the possibility of correction of the negative effects of antenatal hypoxia on the liver tissue homeostasis in 7-day-old albino rats by administration of opioid peptides in a dose of 100 μg/kg on postnatal days 2-6. Administration of mixed μ/δ-opioid receptor agonist Dalargin neutralized deviations of gravimetric indicators, parameters of proliferative activity, and activity of the nucleolar apparatus of hepatocytes. Administration of the non-opiate Leu-enkephalin analogue did not normalize gravimetric parameters and nucleolar apparatus parameters, however, it significantly increased the pool of proliferating hepatocytes. Both peptides significantly reduced the intensity of free radical oxidation, improved antioxidant antiradical defense and resistance to peroxidation in the liver tissue of animals subjected to antenatal hypoxia.