Alteration of brain temperature and systemic inflammation in Parkinson’s disease

• Published in: Neurological sciences Vol. 41; no. 5; pp. 1267 - 1276
• Main Authors: Chen, Hsiu-Ling, Yamada, Kei, Sakai, Koji, Lu, Cheng-Hsien, Chen, Meng-Hsiang, Lin, Wei-Che
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2020; Springer Nature B.V
• Subjects: Age; Aged; Apoptosis; Body Temperature; Brain - physiopathology; Cross-Sectional Studies; Deoxyribonucleic acid; Diffusion Magnetic Resonance Imaging; DNA; Female; Humans; Inflammation; Inflammation - blood; Inflammation - complications; Inflammation - physiopathology; L-selectin; Leukocytes; Male; Medicine; Medicine & Public Health; Middle Aged; Mitochondrial DNA; Movement disorders; Neurodegenerative diseases; Neuroimaging; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Original; Original Article; Oxidative stress; Parkinson Disease - blood; Parkinson Disease - complications; Parkinson Disease - physiopathology; Parkinson's disease; Psychiatry; Retrospective Studies; Thermometry; Autonomic diseases; Oxidative stress; Mitochondrial disorders; Diffusion-weighted MRI
• ISSN: 1590-1874; 1590-3478
• DOI: 10.1007/s10072-019-04217-3

Objectives Parkinson’s disease (PD) is known to be related to various factors, including neuroinflammation, increased oxidative stress, and brain temperature alteration. We aimed to evaluate the correlation between these factors using diffusion-weighted imaging (DWI) thermometry and blood tests of systemic inflammation. Methods From July 2012 to Jun 2017, 103 patients with PD (44 men and 59 women; mean age, 60.43 ± 9.12 years) and 106 sex- and age-matched healthy volunteers (48 men and 58 women; mean age, 58.16 ± 8.45 years) retrospectively underwent magnetic resonance DWI thermometry to estimate brain intraventricular temperature ( T v ). Subjects were divided into three subgroups in light of their ages. The tested inflammatory markers included plasma nuclear DNA, mitochondrial DNA, apoptotic leukocytes, and serum adhesion molecules. The correlations among the T v values, clinical severity, and systemic inflammatory markers were then calculated. Results The PD patients did not show a natural trend of decline in T v with age. Comparisons among the different age groups revealed that the younger PD subjects had significantly lower T v values than the younger controls, but the older subjects had no significant group differences. Overall, the PD patients exhibited lower T v values than the controls, as well as increased oxidative stress. The brain temperature showed positive correlations with inflammatory markers, including plasma nuclear DNA and L-selectin levels, in all the subjects. Conclusions Possible pathophysiological correlations between systemic inflammation and brain temperature were indicated by the results of this study, a finding which may aid us in investigating the underlying pathogenesis of PD.