Random lasing in human tissues embedded with organic dyes for cancer diagnosis

Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetram...

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Bibliographic Details
Published inScientific reports Vol. 7; no. 1; pp. 8385 - 7
Main Authors Wang, Yu, Duan, Zhuojun, Qiu, Zhu, Zhang, Peng, Wu, Jianwei, Zhang, Dingke, Xiang, Tingxiu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 21.08.2017
Nature Publishing Group
Nature Portfolio
Subjects
140/125
631/57/2267
639/624/1020
9/10
Cancer
Diagnosis
Dyes
Ethanol
Feedback
Humanities and Social Sciences
Lasers
Malignancy
Medical diagnosis
Morphology
multidisciplinary
Science
Science (multidisciplinary)
Spectroscopy
Spectrum analysis
Tissues
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Summary:Various nanostructures found in biological organisms are often complex and they exhibit unique optical functions. This study surprisingly found that typical random lasing occurs in cancerous human tissues embedded with the nanotextured organic dye 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7- tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB). Hematoxylin and eosin stain images show that there are more laser resonators in cancerous tissues, caused by a large number of disordered scatters. It is also noteworthy that the random lasing thresholds were found to relate to the tumor malignancy grade. Consequently, the resulting typical random lasing resonators differ between cancerous tissues in different malignancy grades. Further studies are warranted to investigate tissue optical spectroscopy in the field of cancer diagnostics.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-08625-3