Modeling neuron growth using isogeometric collocation based phase field method

We present a new computational framework of neuron growth based on the phase field method and develop an open-source software package called “NeuronGrowth_IGAcollocation”. Neurons consist of a cell body, dendrites, and axons. Axons and dendrites are long processes extending from the cell body and en...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 12; no. 1; pp. 8120 - 10
Main Authors Qian, Kuanren, Pawar, Aishwarya, Liao, Ashlee, Anitescu, Cosmin, Webster-Wood, Victoria, Feinberg, Adam W., Rabczuk, Timon, Zhang, Yongjie Jessica
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 17.05.2022
Nature Publishing Group
Nature Portfolio
Subjects
631/114/116/2392
631/114/2397
Axonogenesis
Axons
Axons - physiology
Cell body
Cytoskeleton
Dendrites
Dendrites - physiology
Geometry
Growth models
Humanities and Social Sciences
Lamellipodia
Mathematical models
Mechanical engineering
Morphology
multidisciplinary
Neurites - physiology
Neurogenesis
Neurons
Neurons - physiology
Pseudopodia
Science
Science (multidisciplinary)
Tubulin
Online AccessGet full text

Cover

More Information
Summary:We present a new computational framework of neuron growth based on the phase field method and develop an open-source software package called “NeuronGrowth_IGAcollocation”. Neurons consist of a cell body, dendrites, and axons. Axons and dendrites are long processes extending from the cell body and enabling information transfer to and from other neurons. There is high variation in neuron morphology based on their location and function, thus increasing the complexity in mathematical modeling of neuron growth. In this paper, we propose a novel phase field model with isogeometric collocation to simulate different stages of neuron growth by considering the effect of tubulin. The stages modeled include lamellipodia formation, initial neurite outgrowth, axon differentiation, and dendrite formation considering the effect of intracellular transport of tubulin on neurite outgrowth. Through comparison with experimental observations, we can demonstrate qualitatively and quantitatively similar reproduction of neuron morphologies at different stages of growth and allow extension towards the formation of neurite networks.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-12073-z