Catalytic enantioselective C(sp3)–H functionalization involving radical intermediates

• Published in: Nature communications Vol. 12; no. 1; pp. 475 - 9
• Main Authors: Zhang, Chi, Li, Zhong-Liang, Gu, Qiang-Shuai, Liu, Xin-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403/933; 639/638/403/935; 639/638/77/883; Acids; Alcohol; Chemistry; Enantiomers; Humanities and Social Sciences; Intermediates; multidisciplinary; Oxidation; Perspective; Science; Science (multidisciplinary); Stereochemistry

Recently, with the boosted development of radical chemistry, enantioselective functionalization of C( sp 3 )–H bonds via a radical pathway has witnessed a renaissance. In principle, two distinct catalytic modes, distinguished by the steps in which the stereochemistry is determined (the radical forma...