Catalytic enantioselective C(sp3)–H functionalization involving radical intermediates

• Published in: Nature communications Vol. 12; no. 1; p. 475
• Main Authors: Zhang, Chi, Li, Zhong-Liang, Gu, Qiang-Shuai, Liu, Xin-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403/933; 639/638/403/935; 639/638/77/883; Acids; Alcohol; Chemistry; Enantiomers; Humanities and Social Sciences; Intermediates; multidisciplinary; Oxidation; Perspective; Science; Science (multidisciplinary); Stereochemistry
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-020-20770-4

Recently, with the boosted development of radical chemistry, enantioselective functionalization of C( sp 3 )–H bonds via a radical pathway has witnessed a renaissance. In principle, two distinct catalytic modes, distinguished by the steps in which the stereochemistry is determined (the radical formation step or the radical functionalization step), can be devised. This Perspective discusses the state-of-the-art in the area of catalytic enantioselective C( sp 3 )–H functionalization involving radical intermediates as well as future challenges and opportunities. Enantioselective functionalization of ubiquitous C(sp 3 )–H bonds via radical species has witnessed a renaissance in the past years. Here, the authors summarize the main achievements in the field by identifying two main reaction pathways determining the stereochemistry and give an outlook on future challenges and opportunities.