Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance

• Published in: Eye (London) Vol. 35; no. 4; pp. 1084 - 1101
• Main Authors: Ting, Darren Shu Jeng, Ho, Charlotte Shan, Deshmukh, Rashmi, Said, Dalia G., Dua, Harminder S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2021; Nature Publishing Group
• Subjects: 692/308/174; 692/499; 692/699/3161/3163; Acanthamoeba Keratitis - drug therapy; Acanthamoeba Keratitis - epidemiology; Anti-Bacterial Agents - therapeutic use; Antimicrobial agents; Antimicrobial resistance; Bacteria; Blindness; Cornea; Degeneration; Developing countries; Drug resistance; Drug Resistance, Bacterial; Epidemiology; Humans; Infections; Keratitis; Laboratory Medicine; LDCs; Medicine; Medicine & Public Health; Microorganisms; Multidrug resistance; Nutrient deficiency; Ophthalmology; Pharmaceutical Sciences/Technology; Review; Review Article; Risk Factors; Surgery; Surgical Oncology; Temporal variations; Trauma
• ISSN: 0950-222X; 1476-5454; 1476-5454
• DOI: 10.1038/s41433-020-01339-3

Corneal opacity is the 5th leading cause of blindness and visual impairment globally, affecting ~6 million of the world population. In addition, it is responsible for 1.5–2.0 million new cases of monocular blindness per year, highlighting an ongoing uncurbed burden on human health. Among all aetiologies such as infection, trauma, inflammation, degeneration and nutritional deficiency, infectious keratitis (IK) represents the leading cause of corneal blindness in both developed and developing countries, with an estimated incidence ranging from 2.5 to 799 per 100,000 population-year. IK can be caused by a wide range of microorganisms, including bacteria, fungi, virus, parasites and polymicrobial infection. Subject to the geographical and temporal variations, bacteria and fungi have been shown to be the most common causative microorganisms for corneal infection. Although viral and Acanthamoeba keratitis are less common, they represent important causes for corneal blindness in the developed countries. Contact lens wear, trauma, ocular surface diseases, lid diseases, and post-ocular surgery have been shown to be the major risk factors for IK. Broad-spectrum topical antimicrobial treatment is the current mainstay of treatment for IK, though its effectiveness is being challenged by the emergence of antimicrobial resistance, including multidrug resistance, in some parts of the world. In this review, we aim to provide an updated review on IK, encompassing the epidemiology, causative microorganisms, major risk factors and the impact of antimicrobial resistance.