Rapid four-component synthesis of dihydropyrano[2,3-c]pyrazoles using nano-eggshell/Ti(IV) as a highly compatible natural based catalyst

• Published in: BMC chemistry Vol. 15; no. 1; pp. 6 - 8
• Main Authors: Dehghani Tafti, Arefeh, Mirjalili, Bi Bi Fatemeh, Bamoniri, Abdolhamid, Salehi, Naeimeh
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 25.01.2021; Springer Nature B.V; BMC
• Subjects: Aldehydes; Biocompatibility; Catalysts; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Dihydropyrano[2,3-c]pyrazole; Eggshell; Emission analysis; Field emission microscopy; Field emission spectroscopy; Fourier transforms; Gravimetric analysis; Green and Sustainable Chemistry; Hydrazines; Malononitrile; Multicomponent reactions; Nano-eggshell/Ti(IV); Natural catalyst; Pyrazole; Research Article; Room temperature; Solvents; Spectrum analysis; Titanium tetrachloride; X-ray spectroscopy; Eggshell; Titanium tetrachloride; Multicomponent reactions; Nano-eggshell/Ti(IV); Dihydropyrano[2,3-c]pyrazole; Natural catalyst
• ISSN: 2661-801X; 2661-801X
• DOI: 10.1186/s13065-021-00734-5

Nano-eggshell/Ti(IV) as a novel naturally based catalyst was prepared, characterized and applied for the synthesis of dihydropyrano[2,3- c ]pyrazole derivatives. The characterization of nano-eggshell/Ti(IV) was performed using Fourier Transform Infrared spectroscopy, X-ray Diffraction, Field Emission Scanning Electron Microscopy, Energy-Dispersive X-ray Spectroscopy, and Thermo Gravimetric Analysis. Dihydropyrano[2,3- c ]pyrazoles were synthesized in the presence of nano-eggshell/Ti(IV) via a four component reaction of aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate at room temperature under solvent free conditions. The principal affairs of this procedure are mild condition, short reaction times, easy work-up, high yields, reusability of the catalyst and the absence of toxic organic solvents.