Fish Oil Supplementation Improves the Repeated-Bout Effect and Redox Balance in 20-30-Year-Old Men Submitted to Strength Training

• Published in: Nutrients Vol. 15; no. 7; p. 1708
• Main Authors: Barquilha, Gustavo, Dos Santos, Cesar Miguel Momesso, Caçula, Kim Guimaraes, Santos, Vinícius Coneglian, Polotow, Tatiana Geraldo, Vasconcellos, Cristina Vardaris, Gomes-Santos, José Alberto Fernandes, Rodrigues, Luiz Eduardo, Lambertucci, Rafael Herling, Serdan, Tamires Duarte Afonso, Levada-Pires, Adriana Cristina, Hatanaka, Elaine, Cury-Boaventura, Maria Fernanda, de Freitas, Paulo Barbosa, Pithon-Curi, Tania Cristina, Masi, Laureane Nunes, Barros, Marcelo Paes, Curi, Rui, Gorjão, Renata, Hirabara, Sandro Massao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.03.2023; MDPI
• Subjects: Antioxidants; C-reactive protein; Creatine; Creatine kinase; Cytokines; Dehydrogenases; Dietary Supplements; Enzymes; Eutrophication; Exercise; Fish; Fish oils; Fish Oils - pharmacology; Fitness training programs; Food and nutrition; Health aspects; Hormones; Humans; Inflammation; Interleukin 6; Interleukins; L-Lactate dehydrogenase; Lactate dehydrogenase; muscle damage; Muscle recovery; Muscle Strength; Muscle, Skeletal; Muscles; Muscular Diseases; n-3 polyunsaturated fatty acids; non-linear strength training; Oxidation-Reduction; Oxidation-reduction reaction; Oxidative stress; Physical fitness; Physical training; Physiological aspects; Plasma; Range of motion; Redox properties; Resistance Training - methods; Sports training; Strength training; Strengthening exercises; Tumor necrosis factor-TNF; Vitamin E; Weight training; Young men; Brazil; non-linear strength training; inflammation; muscle damage; oxidative stress; n-3 polyunsaturated fatty acids
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15071708

Herein, we investigated the effect of fish oil supplementation combined with a strength-training protocol, for 6 weeks, on muscle damage induced by a single bout of strength exercise in untrained young men. Sixteen men were divided into two groups, supplemented or not with fish oil, and they were evaluated at the pre-training period and post-training period. We investigated changes before and 0, 24, and 48 h after a single hypertrophic exercise session. Creatine kinase (CK) and lactate dehydrogenase (LDH) activities, plasma interleukin-6 (IL-6) and C-reactive protein (CRP) levels, and the redox imbalance were increased in response to the single-bout session of hypertrophic exercises at baseline (pre-training period) and decreased during the post-training period in the control group due to the repeated-bout effect (RBE). The fish oil supplementation exacerbated this reduction and improved the redox state. In summary, our findings demonstrate that, in untrained young men submitted to a strength-training protocol, fish oil supplementation is ideal for alleviating the muscle injury, inflammation, and redox imbalance induced by a single session of intense strength exercises, highlighting this supplementation as a beneficial strategy for young men that intend to engage in strength-training programs.