The interplay between immunosenescence and age-related diseases

• Published in: Seminars in immunopathology Vol. 42; no. 5; pp. 545 - 557
• Main Authors: Barbé-Tuana, Florencia, Funchal, Giselle, Schmitz, Carine Raquel Richter, Maurmann, Rafael Moura, Bauer, Moisés E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2020; Springer Nature B.V
• Subjects: Age; Aged; Aging; Autoantibodies; Biomedical and Life Sciences; Biomedicine; CD28 antigen; Cell differentiation; Cellular Senescence; Cytokines; Geriatrics; Humans; Immune system; Immunology; Immunoregulation; Immunosenescence; Inflammation; Internal Medicine; Lymphocytes T; Metabolic disorders; Morbidity; Neurodegenerative diseases; Review; Rheumatoid arthritis; Serum levels; Aging; Inflammaging; Immunosenescence; Cell senescence; Cytokines; T cells
• ISSN: 1863-2297; 1863-2300; 1863-2300
• DOI: 10.1007/s00281-020-00806-z

The aging immune system (immunosenescence) has been implicated with increased morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation (inflammaging) are implicated with several age-related conditions. The expansion of late-differentiated T cells (CD28 − ), regulatory T cells, increased serum levels of autoantibodies, and pro-inflammatory cytokines were implicated with morbidities during aging. Features of accelerated immunosenescence can be identified in adults with chronic inflammatory conditions, such as rheumatoid arthritis, and are predictive of poor clinical outcomes. Therefore, there is an interplay between immunosenescence and age-related diseases. In this review, we discuss how the aging immune system may contribute to the development and clinical course of age-related diseases such as neurodegenerative diseases, rheumatoid arthritis, cancer, cardiovascular, and metabolic diseases.