From bulk, single-cell to spatial RNA sequencing
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RN...
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| Published in | International journal of oral science Vol. 13; no. 1; pp. 36 - 6 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
15.11.2021
Springer Nature B.V Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology. |
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| AbstractList | Abstract RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology. RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology.RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology. RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology. |
| ArticleNumber | 36 |
| Author | Wang, Cun-Yu Li, Xinmin |
| Author_xml | – sequence: 1 givenname: Xinmin surname: Li fullname: Li, Xinmin email: xinminli@mednet.ucla.edu organization: UCLA Technology Center for Genomics & Bioinformatics, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA – sequence: 2 givenname: Cun-Yu surname: Wang fullname: Wang, Cun-Yu email: cwang@dentistry.ucla.edu organization: Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry and Jonsson Comprehensive Cancer Center, UCLA, Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, UCLA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34782601$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1126/science.abb9847 10.1038/s41586-018-0024-3 10.1016/j.jmoldx.2014.03.004 10.1038/s41467-019-10122-2 10.1016/j.cell.2017.10.044 10.1126/science.1159397 10.1038/s41591-018-0197-1 10.1038/s41467-020-19920-5 10.1186/s40425-019-0753-3 10.1186/s13073-017-0467-4 10.1186/s12885-018-5206-8 10.1038/s41568-019-0154-4 10.18632/oncotarget.17098 10.1016/j.cell.2017.01.018 10.1158/2159-8290.CD-15-1545 10.1158/1078-0432.CCR-15-2889 10.1016/j.stem.2021.04.011 10.1038/nrc3612 10.1186/s13059-016-0945-9 10.1126/science.aad0501 10.1038/ncomms5846 10.1016/j.cell.2019.10.003 10.1126/science.aad0095 10.1126/science.1254257 10.1038/s41591-018-0167-7 10.1038/s41592-019-0691-5 10.1002/cam4.1397 10.1038/s41587-019-0392-8 10.1038/s41576-019-0093-7 10.1101/gr.5145806 10.1038/s41596-018-0045-2 10.1002/pros.23004 10.1016/j.cell.2020.08.043 10.1038/nmeth.2281 10.1038/s41576-019-0150-2 10.1158/0008-5472.CAN-18-0747 10.1038/nrg2484 10.1038/nrg2934 10.3892/ijmm.2015.2103 10.1126/science.aaf2403 10.1016/j.ccr.2012.06.005 10.1073/pnas.1900391116 10.1182/blood-2009-03-209262 10.1056/NEJMoa1403088 10.1038/s41591-019-0595-z 10.1038/s41591-018-0198-0 10.1016/j.cell.2020.07.032 10.1073/pnas.1404656111 10.3389/fonc.2019.01361 10.1038/s41467-019-09374-9 10.1038/s41467-018-04724-5 10.1038/nmeth.2801 10.1093/jnci/djw200 10.3390/cells9051130 10.1038/s41592-019-0703-5 10.1101/2021.03.11.434985 |
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| References | Font-Tello (CR13) 2015; 75 Vardiman (CR12) 2009; 114 Cheng (CR39) 2019; 10 Roberts (CR15) 2012; 22 Heyer (CR19) 2019; 10 Chen (CR8) 2016; 6 Stahl (CR44) 2016; 353 Biswas (CR11) 2019; 25 Emrich, Barbazuk, Li, Schnable (CR1) 2007; 17 Cabanski (CR21) 2014; 16 Grauel (CR54) 2020; 11 Gyanchandani (CR10) 2016; 22 Gambino, Tancredi, Falaschi, Aretini, Caligo (CR20) 2015; 35 Guo (CR35) 2018; 24 Wang, Gerstein, Snyder (CR2) 2009; 10 CR7 Han, Li, Cao, Cao, Zhou (CR5) 2018; 7 Stuart, Satija (CR42) 2019; 20 Berglund (CR51) 2018; 9 Lee (CR34) 2014; 111 Arozarena, Wellbrock (CR27) 2019; 19 CR41 McGranahan, Swanton (CR28) 2017; 168 CR40 Kim (CR32) 2016; 17 Thrane, Eriksson, Maaskola, Hansson, Lundeberg (CR50) 2018; 78 Moncada (CR52) 2020; 38 Wang (CR38) 2021; 28 Stransky, Cerami, Schalm, Kim, Lengauer (CR14) 2014; 5 Roberts (CR16) 2014; 371 Dehghannasiri (CR18) 2019; 116 Kabra, Robie, Rivera-Alba, Branson, Branson (CR46) 2013; 10 Tang (CR23) 2017; 8 Su, Zheng, Kinrot, Bintu, Zhuang (CR56) 2020; 182 CR55 Patel (CR29) 2014; 344 Van Allen (CR9) 2015; 350 Ihle (CR47) 2019; 7 Salmen (CR45) 2018; 13 Siriwardhana, Khadka, Chen, Deng (CR24) 2019; 19 Ozsolak, Milos (CR3) 2011; 12 Zhou (CR6) 2019; 9 Zhang (CR37) 2019; 179 Roerink (CR30) 2018; 556 Zhu, Preissl, Ren (CR43) 2020; 17 Krishna (CR36) 2020; 370 CR26 Shaw, Hsu, Awad, Engelman (CR17) 2013; 13 Tirosh (CR33) 2016; 352 Amaria (CR48) 2018; 24 Blank (CR49) 2018; 24 Valle (CR22) 2008; 321 Stark, Grzelak, Hadfield (CR4) 2019; 20 Ji (CR53) 2020; 182 Puram (CR31) 2017; 171 Haque, Engel, Teichmann, Lonnberg (CR25) 2017; 9 N Stransky (146_CR14) 2014; 5 R Dehghannasiri (146_CR18) 2019; 116 SJ Emrich (146_CR1) 2007; 17 JG Zhou (146_CR6) 2019; 9 CU Blank (146_CR49) 2018; 24 PL Chen (146_CR8) 2016; 6 S Krishna (146_CR36) 2020; 370 J-H Su (146_CR56) 2020; 182 AL Ji (146_CR53) 2020; 182 G Gambino (146_CR20) 2015; 35 KT Kim (146_CR32) 2016; 17 SV Puram (146_CR31) 2017; 171 SF Roerink (146_CR30) 2018; 556 F Ozsolak (146_CR3) 2011; 12 C Wang (146_CR38) 2021; 28 RX Tang (146_CR23) 2017; 8 Z Wang (146_CR2) 2009; 10 146_CR41 YH Cheng (146_CR39) 2019; 10 146_CR40 CR Cabanski (146_CR21) 2014; 16 AP Patel (146_CR29) 2014; 344 K Thrane (146_CR50) 2018; 78 LO Han (146_CR5) 2018; 7 146_CR7 EE Heyer (146_CR19) 2019; 10 R Moncada (146_CR52) 2020; 38 R Gyanchandani (146_CR10) 2016; 22 KG Roberts (146_CR15) 2012; 22 D Biswas (146_CR11) 2019; 25 I Tirosh (146_CR33) 2016; 352 X Guo (146_CR35) 2018; 24 M Kabra (146_CR46) 2013; 10 RN Amaria (146_CR48) 2018; 24 AT Shaw (146_CR17) 2013; 13 146_CR55 I Arozarena (146_CR27) 2019; 19 N McGranahan (146_CR28) 2017; 168 CL Ihle (146_CR47) 2019; 7 A Haque (146_CR25) 2017; 9 Q Zhang (146_CR37) 2019; 179 KG Roberts (146_CR16) 2014; 371 AL Grauel (146_CR54) 2020; 11 A Font-Tello (146_CR13) 2015; 75 R Stark (146_CR4) 2019; 20 146_CR26 T Stuart (146_CR42) 2019; 20 C Siriwardhana (146_CR24) 2019; 19 L Valle (146_CR22) 2008; 321 C Zhu (146_CR43) 2020; 17 F Salmen (146_CR45) 2018; 13 E Berglund (146_CR51) 2018; 9 JW Vardiman (146_CR12) 2009; 114 MC Lee (146_CR34) 2014; 111 PL Stahl (146_CR44) 2016; 353 EM Van Allen (146_CR9) 2015; 350 |
| References_xml | – volume: 370 start-page: 1328 year: 2020 end-page: 1334 ident: CR36 article-title: Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer publication-title: Science doi: 10.1126/science.abb9847 – volume: 556 start-page: 457 year: 2018 end-page: 462 ident: CR30 article-title: Intra-tumour diversification in colorectal cancer at the single-cell level publication-title: Nature doi: 10.1038/s41586-018-0024-3 – volume: 16 start-page: 440 year: 2014 end-page: 451 ident: CR21 article-title: cDNA hybrid capture improves transcriptome analysis on low-input and archived samples publication-title: J. Mol. Diagn. doi: 10.1016/j.jmoldx.2014.03.004 – volume: 10 year: 2019 ident: CR39 article-title: Hydro-Seq enables contamination-free high-throughput single-cell RNA-sequencing for circulating tumor cells publication-title: Nat. Commun. doi: 10.1038/s41467-019-10122-2 – volume: 171 start-page: 1611 year: 2017 end-page: 1624 e1624 ident: CR31 article-title: Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer publication-title: Cell doi: 10.1016/j.cell.2017.10.044 – volume: 321 start-page: 1361 year: 2008 end-page: 1365 ident: CR22 article-title: Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer publication-title: Science doi: 10.1126/science.1159397 – volume: 24 start-page: 1649 year: 2018 end-page: 1654 ident: CR48 article-title: Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma publication-title: Nat. Med doi: 10.1038/s41591-018-0197-1 – volume: 11 year: 2020 ident: CR54 article-title: TGFbeta-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts publication-title: Nat. Commun. doi: 10.1038/s41467-020-19920-5 – volume: 7 start-page: 293 year: 2019 ident: CR47 article-title: Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients publication-title: J. Immunother. Cancer doi: 10.1186/s40425-019-0753-3 – volume: 9 year: 2017 ident: CR25 article-title: A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications publication-title: Genome Med doi: 10.1186/s13073-017-0467-4 – volume: 19 year: 2019 ident: CR24 article-title: Development of a miRNA-seq based prognostic signature in lung adenocarcinoma publication-title: BMC Cancer doi: 10.1186/s12885-018-5206-8 – volume: 19 start-page: 377 year: 2019 end-page: 391 ident: CR27 article-title: Phenotype plasticity as enabler of melanoma progression and therapy resistance publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0154-4 – volume: 8 start-page: 50761 year: 2017 end-page: 50773 ident: CR23 article-title: Identification of a RNA-Seq based prognostic signature with five lncRNAs for lung squamous cell carcinoma publication-title: Oncotarget doi: 10.18632/oncotarget.17098 – volume: 168 start-page: 613 year: 2017 end-page: 628 ident: CR28 article-title: Clonal heterogeneity and tumor evolution: past, present, and the future publication-title: Cell doi: 10.1016/j.cell.2017.01.018 – volume: 6 start-page: 827 year: 2016 end-page: 837 ident: CR8 article-title: Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade publication-title: Cancer Disco. doi: 10.1158/2159-8290.CD-15-1545 – volume: 22 start-page: 5362 year: 2016 end-page: 5369 ident: CR10 article-title: Intratumor heterogeneity affects gene expression profile test prognostic risk stratification in early breast cancer publication-title: Clin. Cancer Res doi: 10.1158/1078-0432.CCR-15-2889 – volume: 28 start-page: 1597 year: 2021 end-page: 1613.e7 ident: CR38 article-title: CD276 expression CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance publication-title: Cell Stem Cell doi: 10.1016/j.stem.2021.04.011 – volume: 13 start-page: 772 year: 2013 end-page: 787 ident: CR17 article-title: Tyrosine kinase gene rearrangements in epithelial malignancies publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3612 – volume: 17 year: 2016 ident: CR32 article-title: Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma publication-title: Genome Biol. doi: 10.1186/s13059-016-0945-9 – volume: 352 start-page: 189 year: 2016 end-page: 196 ident: CR33 article-title: Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq publication-title: Science doi: 10.1126/science.aad0501 – volume: 5 year: 2014 ident: CR14 article-title: The landscape of kinase fusions in cancer publication-title: Nat. Commun. doi: 10.1038/ncomms5846 – volume: 179 start-page: 829 year: 2019 end-page: 845 e820 ident: CR37 article-title: Landscape and dynamics of single immune cells in hepatocellular carcinoma publication-title: Cell doi: 10.1016/j.cell.2019.10.003 – volume: 350 start-page: 207 year: 2015 end-page: 211 ident: CR9 article-title: Genomic correlates of response to CTLA-4 blockade in metastatic melanoma publication-title: Science doi: 10.1126/science.aad0095 – volume: 344 start-page: 1396 year: 2014 end-page: 1401 ident: CR29 article-title: Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma publication-title: Science doi: 10.1126/science.1254257 – ident: CR26 – volume: 24 start-page: 1628 year: 2018 ident: CR35 article-title: Publisher Correction: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing publication-title: Nat. Med doi: 10.1038/s41591-018-0167-7 – volume: 17 start-page: 11 year: 2020 end-page: 14 ident: CR43 article-title: Single-cell multimodal omics: the power of many publication-title: Nat. Methods doi: 10.1038/s41592-019-0691-5 – volume: 7 start-page: 1135 year: 2018 end-page: 1140 ident: CR5 article-title: Development and validation of an individualized diagnostic signature in thyroid cancer publication-title: Cancer Med doi: 10.1002/cam4.1397 – volume: 38 start-page: 333 year: 2020 end-page: 342 ident: CR52 article-title: Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas publication-title: Nat. Biotechnol. doi: 10.1038/s41587-019-0392-8 – volume: 20 start-page: 257 year: 2019 end-page: 272 ident: CR42 article-title: Integrative single-cell analysis publication-title: Nat. Rev. Genet doi: 10.1038/s41576-019-0093-7 – volume: 17 start-page: 69 year: 2007 end-page: 73 ident: CR1 article-title: Gene discovery and annotation using LCM-454 transcriptome sequencing publication-title: Genome Res. doi: 10.1101/gr.5145806 – volume: 13 start-page: 2501 year: 2018 end-page: 2534 ident: CR45 article-title: Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections publication-title: Nat. Protoc. doi: 10.1038/s41596-018-0045-2 – volume: 75 start-page: 1216 year: 2015 end-page: 1226 ident: CR13 article-title: Association of ERG and TMPRSS2-ERG with grade, stage, and prognosis of prostate cancer is dependent on their expression levels publication-title: Prostate doi: 10.1002/pros.23004 – volume: 182 start-page: 1661 year: 2020 end-page: 1662 ident: CR53 article-title: Multimodal analysis of composition and spatial architecture in human squamous cell carcinoma publication-title: Cell doi: 10.1016/j.cell.2020.08.043 – volume: 10 start-page: 64 year: 2013 end-page: 67 ident: CR46 article-title: JAABA: interactive machine learning for automatic annotation of animal behavior publication-title: Nat. Methods doi: 10.1038/nmeth.2281 – volume: 20 start-page: 631 year: 2019 end-page: 656 ident: CR4 article-title: RNA sequencing: the teenage years publication-title: Nat. Rev. Genet doi: 10.1038/s41576-019-0150-2 – ident: CR40 – volume: 78 start-page: 5970 year: 2018 end-page: 5979 ident: CR50 article-title: Spatially resolved transcriptomics enables dissection of genetic heterogeneity in stage III cutaneous malignant melanoma publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-18-0747 – volume: 10 start-page: 57 year: 2009 end-page: 63 ident: CR2 article-title: RNA-Seq: a revolutionary tool for transcriptomics publication-title: Nat. Rev. Genet doi: 10.1038/nrg2484 – volume: 12 start-page: 87 year: 2011 end-page: 98 ident: CR3 article-title: RNA sequencing: advances, challenges and opportunities publication-title: Nat. Rev. Genet doi: 10.1038/nrg2934 – volume: 35 start-page: 950 year: 2015 end-page: 956 ident: CR20 article-title: Characterization of three alternative transcripts of the BRCA1 gene in patients with breast cancer and a family history of breast and/or ovarian cancer who tested negative for pathogenic mutations publication-title: Int J. Mol. Med doi: 10.3892/ijmm.2015.2103 – volume: 353 start-page: 78 year: 2016 end-page: 82 ident: CR44 article-title: Visualization and analysis of gene expression in tissue sections by spatial transcriptomics publication-title: Science doi: 10.1126/science.aaf2403 – volume: 22 start-page: 153 year: 2012 end-page: 166 ident: CR15 article-title: Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.06.005 – volume: 116 start-page: 15524 year: 2019 end-page: 15533 ident: CR18 article-title: Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1900391116 – volume: 114 start-page: 937 year: 2009 end-page: 951 ident: CR12 article-title: The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes publication-title: Blood doi: 10.1182/blood-2009-03-209262 – volume: 371 start-page: 1005 year: 2014 end-page: 1015 ident: CR16 article-title: Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa1403088 – volume: 25 start-page: 1540 year: 2019 end-page: 1548 ident: CR11 article-title: A clonal expression biomarker associates with lung cancer mortality publication-title: Nat. Med doi: 10.1038/s41591-019-0595-z – volume: 24 start-page: 1655 year: 2018 end-page: 1661 ident: CR49 article-title: Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma publication-title: Nat. Med doi: 10.1038/s41591-018-0198-0 – volume: 182 start-page: 1641 year: 2020 end-page: 1659.e26 ident: CR56 article-title: Genome-scale imaging of the 3D organization and transcriptional activity of chromatin publication-title: Cell doi: 10.1016/j.cell.2020.07.032 – volume: 111 start-page: E4726 year: 2014 end-page: E4735 ident: CR34 article-title: Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1404656111 – volume: 9 start-page: 1361 year: 2019 ident: CR6 article-title: Development and validation of an RNA-seq-based prognostic signature in neuroblastoma publication-title: Front Oncol. doi: 10.3389/fonc.2019.01361 – ident: CR55 – ident: CR7 – volume: 10 year: 2019 ident: CR19 article-title: Diagnosis of fusion genes using targeted RNA sequencing publication-title: Nat. Commun. doi: 10.1038/s41467-019-09374-9 – ident: CR41 – volume: 9 year: 2018 ident: CR51 article-title: Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity publication-title: Nat. Commun. doi: 10.1038/s41467-018-04724-5 – volume: 7 start-page: 1135 year: 2018 ident: 146_CR5 publication-title: Cancer Med doi: 10.1002/cam4.1397 – volume: 6 start-page: 827 year: 2016 ident: 146_CR8 publication-title: Cancer Disco. doi: 10.1158/2159-8290.CD-15-1545 – volume: 116 start-page: 15524 year: 2019 ident: 146_CR18 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1900391116 – volume: 353 start-page: 78 year: 2016 ident: 146_CR44 publication-title: Science doi: 10.1126/science.aaf2403 – volume: 78 start-page: 5970 year: 2018 ident: 146_CR50 publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-18-0747 – volume: 22 start-page: 153 year: 2012 ident: 146_CR15 publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.06.005 – volume: 344 start-page: 1396 year: 2014 ident: 146_CR29 publication-title: Science doi: 10.1126/science.1254257 – volume: 19 start-page: 377 year: 2019 ident: 146_CR27 publication-title: Nat. Rev. Cancer doi: 10.1038/s41568-019-0154-4 – volume: 19 year: 2019 ident: 146_CR24 publication-title: BMC Cancer doi: 10.1186/s12885-018-5206-8 – ident: 146_CR41 doi: 10.1038/nmeth.2801 – ident: 146_CR7 doi: 10.1093/jnci/djw200 – volume: 38 start-page: 333 year: 2020 ident: 146_CR52 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-019-0392-8 – volume: 8 start-page: 50761 year: 2017 ident: 146_CR23 publication-title: Oncotarget doi: 10.18632/oncotarget.17098 – volume: 321 start-page: 1361 year: 2008 ident: 146_CR22 publication-title: Science doi: 10.1126/science.1159397 – volume: 24 start-page: 1628 year: 2018 ident: 146_CR35 publication-title: Nat. Med doi: 10.1038/s41591-018-0167-7 – volume: 9 year: 2018 ident: 146_CR51 publication-title: Nat. Commun. doi: 10.1038/s41467-018-04724-5 – volume: 75 start-page: 1216 year: 2015 ident: 146_CR13 publication-title: Prostate doi: 10.1002/pros.23004 – volume: 10 year: 2019 ident: 146_CR39 publication-title: Nat. Commun. doi: 10.1038/s41467-019-10122-2 – volume: 13 start-page: 772 year: 2013 ident: 146_CR17 publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3612 – volume: 168 start-page: 613 year: 2017 ident: 146_CR28 publication-title: Cell doi: 10.1016/j.cell.2017.01.018 – volume: 17 year: 2016 ident: 146_CR32 publication-title: Genome Biol. doi: 10.1186/s13059-016-0945-9 – volume: 20 start-page: 257 year: 2019 ident: 146_CR42 publication-title: Nat. Rev. Genet doi: 10.1038/s41576-019-0093-7 – volume: 10 year: 2019 ident: 146_CR19 publication-title: Nat. Commun. doi: 10.1038/s41467-019-09374-9 – volume: 179 start-page: 829 year: 2019 ident: 146_CR37 publication-title: Cell doi: 10.1016/j.cell.2019.10.003 – volume: 22 start-page: 5362 year: 2016 ident: 146_CR10 publication-title: Clin. Cancer Res doi: 10.1158/1078-0432.CCR-15-2889 – ident: 146_CR26 doi: 10.3390/cells9051130 – volume: 11 year: 2020 ident: 146_CR54 publication-title: Nat. Commun. doi: 10.1038/s41467-020-19920-5 – volume: 17 start-page: 69 year: 2007 ident: 146_CR1 publication-title: Genome Res. doi: 10.1101/gr.5145806 – volume: 171 start-page: 1611 year: 2017 ident: 146_CR31 publication-title: Cell doi: 10.1016/j.cell.2017.10.044 – volume: 10 start-page: 64 year: 2013 ident: 146_CR46 publication-title: Nat. Methods doi: 10.1038/nmeth.2281 – volume: 371 start-page: 1005 year: 2014 ident: 146_CR16 publication-title: N. Engl. J. Med doi: 10.1056/NEJMoa1403088 – volume: 28 start-page: 1597 year: 2021 ident: 146_CR38 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2021.04.011 – volume: 35 start-page: 950 year: 2015 ident: 146_CR20 publication-title: Int J. Mol. Med doi: 10.3892/ijmm.2015.2103 – ident: 146_CR40 doi: 10.1038/s41592-019-0703-5 – volume: 111 start-page: E4726 year: 2014 ident: 146_CR34 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1404656111 – volume: 7 start-page: 293 year: 2019 ident: 146_CR47 publication-title: J. Immunother. Cancer doi: 10.1186/s40425-019-0753-3 – volume: 13 start-page: 2501 year: 2018 ident: 146_CR45 publication-title: Nat. Protoc. doi: 10.1038/s41596-018-0045-2 – ident: 146_CR55 doi: 10.1101/2021.03.11.434985 – volume: 556 start-page: 457 year: 2018 ident: 146_CR30 publication-title: Nature doi: 10.1038/s41586-018-0024-3 – volume: 20 start-page: 631 year: 2019 ident: 146_CR4 publication-title: Nat. Rev. Genet doi: 10.1038/s41576-019-0150-2 – volume: 9 start-page: 1361 year: 2019 ident: 146_CR6 publication-title: Front Oncol. doi: 10.3389/fonc.2019.01361 – volume: 352 start-page: 189 year: 2016 ident: 146_CR33 publication-title: Science doi: 10.1126/science.aad0501 – volume: 17 start-page: 11 year: 2020 ident: 146_CR43 publication-title: Nat. Methods doi: 10.1038/s41592-019-0691-5 – volume: 12 start-page: 87 year: 2011 ident: 146_CR3 publication-title: Nat. Rev. Genet doi: 10.1038/nrg2934 – volume: 5 year: 2014 ident: 146_CR14 publication-title: Nat. Commun. doi: 10.1038/ncomms5846 – volume: 10 start-page: 57 year: 2009 ident: 146_CR2 publication-title: Nat. Rev. Genet doi: 10.1038/nrg2484 – volume: 9 year: 2017 ident: 146_CR25 publication-title: Genome Med doi: 10.1186/s13073-017-0467-4 – volume: 25 start-page: 1540 year: 2019 ident: 146_CR11 publication-title: Nat. Med doi: 10.1038/s41591-019-0595-z – volume: 24 start-page: 1649 year: 2018 ident: 146_CR48 publication-title: Nat. Med doi: 10.1038/s41591-018-0197-1 – volume: 24 start-page: 1655 year: 2018 ident: 146_CR49 publication-title: Nat. Med doi: 10.1038/s41591-018-0198-0 – volume: 182 start-page: 1641 year: 2020 ident: 146_CR56 publication-title: Cell doi: 10.1016/j.cell.2020.07.032 – volume: 182 start-page: 1661 year: 2020 ident: 146_CR53 publication-title: Cell doi: 10.1016/j.cell.2020.08.043 – volume: 16 start-page: 440 year: 2014 ident: 146_CR21 publication-title: J. Mol. Diagn. doi: 10.1016/j.jmoldx.2014.03.004 – volume: 350 start-page: 207 year: 2015 ident: 146_CR9 publication-title: Science doi: 10.1126/science.aad0095 – volume: 370 start-page: 1328 year: 2020 ident: 146_CR36 publication-title: Science doi: 10.1126/science.abb9847 – volume: 114 start-page: 937 year: 2009 ident: 146_CR12 publication-title: Blood doi: 10.1182/blood-2009-03-209262 |
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| Snippet | RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more... Abstract RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a... |
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| SubjectTerms | 631/114/2785 631/208/514/1949 Dentistry DNA sequencing Exome Sequencing Gene expression Humans Medicine Neoplasms Oral and Maxillofacial Surgery Orthopedics Precision Medicine Review Review Article Ribonucleic acid RNA Sequence Analysis, RNA Surgical Orthopedics |
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| Title | From bulk, single-cell to spatial RNA sequencing |
| URI | https://link.springer.com/article/10.1038/s41368-021-00146-0 https://www.ncbi.nlm.nih.gov/pubmed/34782601 https://www.proquest.com/docview/2597613384 https://www.proquest.com/docview/2598079559 https://pubmed.ncbi.nlm.nih.gov/PMC8593179 https://doaj.org/article/83b2ddf152304608adbe69c6ad05caf9 |
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