Isolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment

• Published in: Scientific reports Vol. 12; no. 1; pp. 19250 - 13
• Main Authors: Manimaran, Dharmar, Elangovan, Namasivayam, Mani, Panagal, Subramanian, Kumaran, Ali, Daoud, Alarifi, Saud, Palanisamy, Chella Perumal, Zhang, Hongxia, Rangasamy, Kowsalya, Palanisamy, Vasan, Mani, Renuka, Govarthanan, Kavitha, Aruni, Wilson, Shanmugam, Rajeshkumar, Srinivasan, Guru Prasad, Kalirajan, Aruncahllam
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/152; 631/154/436; Acids; Biotechnology; Cancer; Cancer therapies; Chitosan; Chitosan - chemistry; Drug Carriers - chemistry; Drug delivery systems; Drug resistance; Fourier transforms; Humanities and Social Sciences; Infrared spectroscopy; Medical research; Microscopy; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; multidisciplinary; Multidrug resistance; Nanoparticles; Nanoparticles - chemistry; Neoplasms - drug therapy; Parkinson's disease; Particle Size; Polymers; Scanning electron microscopy; Science; Science (multidisciplinary); Sodium; Solid tumors; Spectroscopy, Fourier Transform Infrared; Transmission electron microscopy; X-Ray Diffraction
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-23386-4

Recent breakthroughs in the field of nanoparticle-based therapeutic delivery methods have changed the standpoint of cancer therapy by effectively delaying the process of disease development. Nanoparticles have a unique capacity of good penetrating ability than other therapeutic leads used in traditional therapeutics, and also, they have the highest impact on disease management. In the current study isolongifolene-loaded Chitosan nanoparticles have been formulated, synthesized and then characterized by the use of Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Further, the characterized chitosan nano formulation was evaluated for hemocompatibility, plasma stability, and in-vitro release. Isolongifolene-loaded chitosan nanoparticles were found to be compatible with plasma and also, they exhibited a constant release pattern. Hence, chitosan-loaded nanoparticles could be employed as an excellent adjuvant in cancer therapeutic, to combat the multi-drug resistance in solid tumors.