Research progress on the biological modifications of implant materials in 3D printed intervertebral fusion cages

Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain intervertebral height and provide a bone graft window. Titanium fusion cages are the most widely used metal material in spinal clinical applications. H...

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Published inJournal of materials science. Materials in medicine Vol. 33; no. 1; p. 2
Main Authors Li, Shan, Huan, Yifan, Zhu, Bin, Chen, Haoxiang, Tang, Ming, Yan, Yiguo, Wang, Cheng, Ouyang, Zhihua, Li, Xuelin, Xue, Jingbo, Wang, Wenjun
Format Journal Article
LanguageEnglish
Published New York Springer US 01.01.2022
Springer Nature B.V
Springer
Subjects
Animals
Back surgery
Biocompatibility
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Bioengineering
Biological activity
Biological materials
Biomaterials
Biomedical Engineering and Bioengineering
Biomedical materials
Biomedical Research - methods
Biomedical Research - trends
Bone grafts
Bone Substitutes - chemical synthesis
Bone Substitutes - chemistry
Bone surgery
Bone Transplantation - instrumentation
Bone Transplantation - methods
Bone Transplantation - trends
Cages
Cell differentiation
Cell fusion
Ceramics
Chemistry and Materials Science
Clinical Applications of Biomaterials
Complications
Composites
Decompression
Differentiation (biology)
Endoscopy
Glass
Grafting
Grafts
Humans
Manufacturing industry
Materials Science
Natural Materials
Polymer Sciences
Printing, Three-Dimensional - trends
Prostheses and Implants
Prosthesis Design - methods
Prosthesis Design - trends
Regenerative Medicine/Tissue Engineering
Skin & tissue grafts
Spinal Fusion - instrumentation
Spinal Fusion - methods
Spinal Fusion - trends
Spine
Substitute bone
Surfaces and Interfaces
Surgery
Surgical implants
Thin Films
Three dimensional printing
Titanium
Online AccessGet full text

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Abstract Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain intervertebral height and provide a bone graft window. Titanium fusion cages are the most widely used metal material in spinal clinical applications. However, there is a certain incidence of complications in clinical follow-ups, such as pseudoarticulation formation and implant displacement due to nonfusion of bone grafts in the cage. With the deepening research on metal materials, the properties of these materials have been developed from being biologically inert to having biological activity and biological functionalization, promoting adhesion, cell differentiation, and bone fusion. In addition, 3D printing, thin-film, active biological material, and 4D bioprinting technology are also being used in the biofunctionalization and intelligent advanced manufacturing processes of implant devices in the spine. This review focuses on the biofunctionalization of implant materials in 3D printed intervertebral fusion cages. The surface modifications of implant materials in metal endoscopy, material biocompatibility, and bioactive functionalizationare summarized. Furthermore, the prospects and challenges of the biofunctionalization of implant materials in spinal surgery are discussed. Fig.a.b.c.d.e.f.g As a pre-selected image for the cover, I really look forward to being selected. Special thanks to you for your comments.
AbstractList Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain intervertebral height and provide a bone graft window. Titanium fusion cages are the most widely used metal material in spinal clinical applications. However, there is a certain incidence of complications in clinical follow-ups, such as pseudoarticulation formation and implant displacement due to nonfusion of bone grafts in the cage. With the deepening research on metal materials, the properties of these materials have been developed from being biologically inert to having biological activity and biological functionalization, promoting adhesion, cell differentiation, and bone fusion. In addition, 3D printing, thin-film, active biological material, and 4D bioprinting technology are also being used in the biofunctionalization and intelligent advanced manufacturing processes of implant devices in the spine. This review focuses on the biofunctionalization of implant materials in 3D printed intervertebral fusion cages. The surface modifications of implant materials in metal endoscopy, material biocompatibility, and bioactive functionalizationare summarized. Furthermore, the prospects and challenges of the biofunctionalization of implant materials in spinal surgery are discussed. Fig.a.b.c.d.e.f.g As a pre-selected image for the cover, I really look forward to being selected. Special thanks to you for your comments.
Abstract Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain intervertebral height and provide a bone graft window. Titanium fusion cages are the most widely used metal material in spinal clinical applications. However, there is a certain incidence of complications in clinical follow-ups, such as pseudoarticulation formation and implant displacement due to nonfusion of bone grafts in the cage. With the deepening research on metal materials, the properties of these materials have been developed from being biologically inert to having biological activity and biological functionalization, promoting adhesion, cell differentiation, and bone fusion. In addition, 3D printing, thin-film, active biological material, and 4D bioprinting technology are also being used in the biofunctionalization and intelligent advanced manufacturing processes of implant devices in the spine. This review focuses on the biofunctionalization of implant materials in 3D printed intervertebral fusion cages. The surface modifications of implant materials in metal endoscopy, material biocompatibility, and bioactive functionalizationare summarized. Furthermore, the prospects and challenges of the biofunctionalization of implant materials in spinal surgery are discussed.
Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain intervertebral height and provide a bone graft window. Titanium fusion cages are the most widely used metal material in spinal clinical applications. However, there is a certain incidence of complications in clinical follow-ups, such as pseudoarticulation formation and implant displacement due to nonfusion of bone grafts in the cage. With the deepening research on metal materials, the properties of these materials have been developed from being biologically inert to having biological activity and biological functionalization, promoting adhesion, cell differentiation, and bone fusion. In addition, 3D printing, thin-film, active biological material, and 4D bioprinting technology are also being used in the biofunctionalization and intelligent advanced manufacturing processes of implant devices in the spine. This review focuses on the biofunctionalization of implant materials in 3D printed intervertebral fusion cages. The surface modifications of implant materials in metal endoscopy, material biocompatibility, and bioactive functionalizationare summarized. Furthermore, the prospects and challenges of the biofunctionalization of implant materials in spinal surgery are discussed. Fig.a.b.c.d.e.f.g As a pre-selected image for the cover, I really look forward to being selected. Special thanks to you for your comments.
Abstract Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain intervertebral height and provide a bone graft window. Titanium fusion cages are the most widely used metal material in spinal clinical applications. However, there is a certain incidence of complications in clinical follow-ups, such as pseudoarticulation formation and implant displacement due to nonfusion of bone grafts in the cage. With the deepening research on metal materials, the properties of these materials have been developed from being biologically inert to having biological activity and biological functionalization, promoting adhesion, cell differentiation, and bone fusion. In addition, 3D printing, thin-film, active biological material, and 4D bioprinting technology are also being used in the biofunctionalization and intelligent advanced manufacturing processes of implant devices in the spine. This review focuses on the biofunctionalization of implant materials in 3D printed intervertebral fusion cages. The surface modifications of implant materials in metal endoscopy, material biocompatibility, and bioactive functionalizationare summarized. Furthermore, the prospects and challenges of the biofunctionalization of implant materials in spinal surgery are discussed. Fig.a.b.c.d.e.f.g As a pre-selected image for the cover, I really look forward to being selected. Special thanks to you for your comments.
Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain intervertebral height and provide a bone graft window. Titanium fusion cages are the most widely used metal material in spinal clinical applications. However, there is a certain incidence of complications in clinical follow-ups, such as pseudoarticulation formation and implant displacement due to nonfusion of bone grafts in the cage. With the deepening research on metal materials, the properties of these materials have been developed from being biologically inert to having biological activity and biological functionalization, promoting adhesion, cell differentiation, and bone fusion. In addition, 3D printing, thin-film, active biological material, and 4D bioprinting technology are also being used in the biofunctionalization and intelligent advanced manufacturing processes of implant devices in the spine. This review focuses on the biofunctionalization of implant materials in 3D printed intervertebral fusion cages. The surface modifications of implant materials in metal endoscopy, material biocompatibility, and bioactive functionalizationare summarized. Furthermore, the prospects and challenges of the biofunctionalization of implant materials in spinal surgery are discussed.
ArticleNumber 2
Author Huan, Yifan
Chen, Haoxiang
Li, Shan
Ouyang, Zhihua
Zhu, Bin
Tang, Ming
Wang, Cheng
Yan, Yiguo
Xue, Jingbo
Wang, Wenjun
Li, Xuelin
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  organization: Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34940930$$D View this record in MEDLINE/PubMed
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Issue 1
Language English
License 2021. The Author(s).
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PublicationTitle Journal of materials science. Materials in medicine
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Snippet Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain...
Abstract Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain...
Abstract Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain...
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SubjectTerms Animals
Back surgery
Biocompatibility
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Bioengineering
Biological activity
Biological materials
Biomaterials
Biomedical Engineering and Bioengineering
Biomedical materials
Biomedical Research - methods
Biomedical Research - trends
Bone grafts
Bone Substitutes - chemical synthesis
Bone Substitutes - chemistry
Bone surgery
Bone Transplantation - instrumentation
Bone Transplantation - methods
Bone Transplantation - trends
Cages
Cell differentiation
Cell fusion
Ceramics
Chemistry and Materials Science
Clinical Applications of Biomaterials
Complications
Composites
Decompression
Differentiation (biology)
Endoscopy
Glass
Grafting
Grafts
Humans
Manufacturing industry
Materials Science
Natural Materials
Polymer Sciences
Printing, Three-Dimensional - trends
Prostheses and Implants
Prosthesis Design - methods
Prosthesis Design - trends
Regenerative Medicine/Tissue Engineering
Skin & tissue grafts
Spinal Fusion - instrumentation
Spinal Fusion - methods
Spinal Fusion - trends
Spine
Substitute bone
Surfaces and Interfaces
Surgery
Surgical implants
Thin Films
Three dimensional printing
Titanium
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Title Research progress on the biological modifications of implant materials in 3D printed intervertebral fusion cages
URI https://link.springer.com/article/10.1007/s10856-021-06609-4
https://www.ncbi.nlm.nih.gov/pubmed/34940930
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Volume 33
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