Research progress on the biological modifications of implant materials in 3D printed intervertebral fusion cages

• Published in: Journal of materials science. Materials in medicine Vol. 33; no. 1; p. 2
• Main Authors: Li, Shan, Huan, Yifan, Zhu, Bin, Chen, Haoxiang, Tang, Ming, Yan, Yiguo, Wang, Cheng, Ouyang, Zhihua, Li, Xuelin, Xue, Jingbo, Wang, Wenjun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2022; Springer Nature B.V; Springer
• Subjects: Animals; Back surgery; Biocompatibility; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Bioengineering; Biological activity; Biological materials; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Biomedical Research - methods; Biomedical Research - trends; Bone grafts; Bone Substitutes - chemical synthesis; Bone Substitutes - chemistry; Bone surgery; Bone Transplantation - instrumentation; Bone Transplantation - methods; Bone Transplantation - trends; Cages; Cell differentiation; Cell fusion; Ceramics; Chemistry and Materials Science; Clinical Applications of Biomaterials; Complications; Composites; Decompression; Differentiation (biology); Endoscopy; Glass; Grafting; Grafts; Humans; Manufacturing industry; Materials Science; Natural Materials; Polymer Sciences; Printing, Three-Dimensional - trends; Prostheses and Implants; Prosthesis Design - methods; Prosthesis Design - trends; Regenerative Medicine/Tissue Engineering; Skin & tissue grafts; Spinal Fusion - instrumentation; Spinal Fusion - methods; Spinal Fusion - trends; Spine; Substitute bone; Surfaces and Interfaces; Surgery; Surgical implants; Thin Films; Three dimensional printing; Titanium
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-021-06609-4

Anterior spine decompression and reconstruction with bone grafts and fusion is a routine spinal surgery. The intervertebral fusion cage can maintain intervertebral height and provide a bone graft window. Titanium fusion cages are the most widely used metal material in spinal clinical applications. However, there is a certain incidence of complications in clinical follow-ups, such as pseudoarticulation formation and implant displacement due to nonfusion of bone grafts in the cage. With the deepening research on metal materials, the properties of these materials have been developed from being biologically inert to having biological activity and biological functionalization, promoting adhesion, cell differentiation, and bone fusion. In addition, 3D printing, thin-film, active biological material, and 4D bioprinting technology are also being used in the biofunctionalization and intelligent advanced manufacturing processes of implant devices in the spine. This review focuses on the biofunctionalization of implant materials in 3D printed intervertebral fusion cages. The surface modifications of implant materials in metal endoscopy, material biocompatibility, and bioactive functionalizationare summarized. Furthermore, the prospects and challenges of the biofunctionalization of implant materials in spinal surgery are discussed. Fig.a.b.c.d.e.f.g As a pre-selected image for the cover, I really look forward to being selected. Special thanks to you for your comments.