Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients

• Published in: Scientific reports Vol. 7; no. 1; pp. 8280 - 10
• Main Authors: Al-Daghri, Nasser M., Mohammed, Abdul Khader, Al-Attas, Omar S., Ansari, Mohammed Ghouse Ahmed, Wani, Kaiser, Hussain, Syed D., Sabico, Shaun, Tripathi, Gyanendra, Alokail, Majed S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.08.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 692/163/2743; 692/53; 82; 82/47; Cholesterol; Diabetes; Diabetes mellitus; Genetic diversity; Genotypes; Genotyping; Humanities and Social Sciences; Insulin; Low density lipoprotein; Metabolism; multidisciplinary; Science; Science (multidisciplinary); Supplements; Triglycerides; Vitamin D; Vitamin D receptors; Vitamin D3
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-08621-7

There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. A total of 204 T2DM subjects received 2000 IU vitamin D3 daily for 12 months. Serum 25(OH)D and metabolic profiles were measured at baseline and after 12 months. VDR polymorphisms ( Taq-I, Bsm-I, Apa-I and Fok-I ) were identified using TaqMan genotyping assays. Vitamin D supplementation significantly increased HOMA β-cell function (p = 0.003) as well as significantly decreased triglycerides, total and LDL-cholesterol (p < 0.001). The lowest increment in 25(OH)D levels was detected in patients with Fok-I CC genotypes (p < 0.0001). With vitamin D supplementation, Taq-I GG genotype carriers showed significant improvements in triglycerides, LDL- and total cholesterol, insulin, HbA1c and HOMA-IR (p < 0.005, 0.01, < 0.001, < 0.005, 0.03 and 0.01, respectively). Similarly, Bsm-I TT genotype carriers showed significant improvements in triglycerides (p = 0.01), insulin and HOMA-IR (p-values < 0.05). In conclusion, improvements in metabolic profile due to vitamin D supplementation is influenced by VDR polymorphisms, specifically for carriers of Taq-I GG and Bsm-I TT genotypes.