Tannin–Mn coordination polymer coated carbon quantum dots nanocomposite for fluorescence and magnetic resonance bimodal imaging

• Published in: Journal of materials science. Materials in medicine Vol. 33; no. 2; pp. 16 - 11
• Main Authors: Xu, Weibing, Zhang, Jia, Yang, Zhijie, Zhao, Minzhi, Long, Haitao, Wu, Qingfeng, Nian, Fang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2022; Springer Nature B.V; Springer
• Subjects: Biomaterials; Biomaterials Synthesis and Characterization; Biomedical Engineering and Bioengineering; Biomedical materials; Carbon; Ceramics; Chemistry and Materials Science; Composites; Coordination polymers; Fluorescence; Glass; Hep G2 Cells; Humans; Magnetic Resonance Imaging; Manganese - chemistry; Materials Science; Metabolic pathways; Nanocomposites; Nanocomposites - chemistry; Natural Materials; Optical Imaging; Organs; Phenolic compounds; Phenols; Polymer coatings; Polymer Sciences; Polymers; Polymers - chemistry; Quantum dots; Quantum Dots - chemistry; Regenerative Medicine/Tissue Engineering; Surfaces and Interfaces; Tannins - chemistry; Thin Films; X ray photoelectron spectroscopy
• ISSN: 0957-4530; 1573-4838; 1573-4838
• DOI: 10.1007/s10856-021-06629-0

The MR/FI bimodal imaging has attracted widely studied due to combining the advantages of MRI and FI can bridge gaps in sensitivity and depth between these two modalities. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by coating the Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The structure of the as-prepared nanocomposite probe is carefully validated via SEM, TEM, and XPS. The content of Mn 2+ is calculated through the EDS and TGA. The quantum yield (QY) and emission wavelength of the probe are about 7.24% and 490 nm, respectively. The longitudinal r1 value (2.43 mM −1 s −1 ) with low r2/r1 (4.45) of the probe is obtained. Subsequently, fluorescence and MR imaging are performed. The metabolic pathways in vivo are inferred by studying the bio-distribution of the probe in major organs. Thus, these results indicate that probe would be an excellent dual-modal imaging probe for enhanced MR imaging and fluorescence imaging. MR/FI bimodal imaging probe is built via in-situ coated Mn-phenolic coordination polymer on the surface of the carbon quantum dots. The in vitro and vivo image property of the probe is evaluated.