Glycemic Index, Glycemic Load, and FAS rs6586161 Polymorphism in Relation to Gastric Cancer Risk: A Case-Control Study in Korea

• Published in: Nutrients Vol. 15; no. 14; p. 3238
• Main Authors: Kim, Hong Kyoung, Kim, Sang Young, Kwak, Jung Hyun, Kim, Hyun Ja
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2023; MDPI
• Subjects: Alcohol use; Apoptosis; Body mass index; Cancer; Carbohydrates; case-control study; Cell growth; Data collection; Diet; DNA methylation; Energy consumption; FAS; Food; Gastric cancer; Genes; Genetic aspects; Glucose; Glycemic index; glycemic load; Health aspects; Infections; Middle schools; Nutrition research; Oncology, Experimental; Polymorphism; Regression analysis; Risk factors; single-nucleotide polymorphisms; Stomach cancer; Surveys; Thoracic surgery; South Korea; United States > US; glycemic index; gastric cancer; case-control study; FAS; glycemic load; single-nucleotide polymorphisms; rs6586161
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15143238

Many dietary and genetic factors have been confirmed to be associated with gastric cancer risk. This research investigated gastric cancer risk with regard to the glycemic index, glycemic load, and FAS rs6586161 polymorphism. A total of 232 matched pairs were included in this case-control study. Data collection was conducted at two hospitals in Korea from 2002 to 2006. Dietary information was obtained from a food frequency questionnaire, and genotypes of FAS rs6586161 polymorphism were TT, TA, and AA type. Gastric cancer risk was increased for the highest tertile of glycemic index (vs. lowest tertile, OR = 1.84, 95% CI = 1.07-3.18), the highest tertile of glycemic load (vs. lowest tertile, OR = 2.14, 95% CI = 1.23-3.75), and the AA type of FAS rs6586161 polymorphism (vs. TT types, OR = 1.95, 95% CI = 1.13-3.39). Furthermore, gastric cancer risk was significantly elevated for the participants with the highest glycemic load and AA type of FAS rs6586161 polymorphism (vs. the lowest glycemic load and TT type, OR = 5.53, 95% CI = 2.01-15.21). Both the high glycemic load and AA type of FAS rs6586161 polymorphism increased gastric cancer risk; however, the interactions between these two elevated the risk of gastric cancer even more.