Genetic analysis of integrin activation in T lymphocytes
Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work o...
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Published in | Immunological reviews Vol. 186; no. 1; pp. 172 - 188 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Munksgaard International Publishers
01.08.2002
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Subjects | |
Online Access | Get full text |
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Summary: | Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work over the past 2 decades has attempted to define the signaling pathways leading from the CD3/TCR complex that culminate ultimately in the functions necessary for effective T cell immune responses, such as cytokine production. Here, we summarize recent advances in our understanding of the mechanisms by which the CD3/TCR complex controls integrin‐mediated T cell adhesion, and discuss new information that suggests that there may be unexpected facets to this pathway that distinguish it from those previously defined. |
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Bibliography: | ArticleID:imrais010 istex:657E60DA97B53D97BBDFAD3AE78F0C263B14297D ark:/67375/WNG-9GJT4FTK-4 Sirid‐Aimée Kellermann Cheryl L. Dell Stephen W. Hunt III Yoji Shimizu ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0105-2896 1600-065X |
DOI: | 10.1034/j.1600-065X.2002.18615.x |