Recent advances in understanding Pseudomonas aeruginosa as a pathogen [version 1; peer review: 3 approved]

The versatile and ubiquitous Pseudomonas aeruginosa is an opportunistic pathogen causing acute and chronic infections in predisposed human subjects. Here we review recent progress in understanding P. aeruginosa population biology and virulence, its cyclic di-GMP-mediated switches of lifestyle, and i...

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Bibliographic Details
Published inF1000 research Vol. 6; p. 1261
Main Authors Klockgether, Jens, Tümmler, Burkhard
Format Journal Article
LanguageEnglish
Published England Faculty of 1000 Ltd 2017
F1000Research
F1000 Research Ltd
Subjects
Bacterial Infections
Cellular Microbiology & Pathogenesis
Immunity to Infections
Innate Immunity
Leukocyte Signaling & Gene Expression
Medical Microbiology
Microbial Evolution & Genomics
Microbial Physiology & Metabolism
Respiratory Infections
Respiratory Pediatrics
Review
Pseudomonas aeruginosa
T3SS
c-di-GMP
type VI secretion system
T6SS
type III secretion system
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Summary:The versatile and ubiquitous Pseudomonas aeruginosa is an opportunistic pathogen causing acute and chronic infections in predisposed human subjects. Here we review recent progress in understanding P. aeruginosa population biology and virulence, its cyclic di-GMP-mediated switches of lifestyle, and its interaction with the mammalian host as well as the role of the type III and type VI secretion systems in P. aeruginosa infection.
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Competing interests: The authors declare that they have no competing interests.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.10506.1