Survival of retinal ganglion cells after damage to the occipital lobe in humans is activity dependent

• Published in: Proceedings of the Royal Society. B, Biological sciences Vol. 286; no. 1897; p. 20182733
• Main Authors: Schneider, Colleen L, Prentiss, Emily K, Busza, Ania, Matmati, Kelly, Matmati, Nabil, Williams, Zoë R, Sahin, Bogachan, Mahon, Bradford Z
• Format: Journal Article
• Language: English
• Published: England The Royal Society 27.02.2019
• Subjects: Adult; Aged; Blindness - etiology; Blindness - physiopathology; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroscience and Cognition; Occipital Lobe - physiology; Prospective Studies; Retinal Ganglion Cells - physiology; Retrograde Degeneration - etiology; Retrograde Degeneration - physiopathology; Stroke - complications; Tomography, Optical Coherence; Visual Field Tests; Visual Pathways - physiopathology; retinal ganglion cells; retinotopic mapping; optical coherence tomography; stroke; functional magnetic resonance imaging; homonymous hemianopia
• ISSN: 0962-8452; 1471-2954
• DOI: 10.1098/rspb.2018.2733

Damage to the optic radiations or primary visual cortex leads to blindness in all or part of the contralesional visual field. Such damage disconnects the retina from its downstream targets and, over time, leads to trans-synaptic retrograde degeneration of retinal ganglion cells. To date, visual ability is the only predictor of retinal ganglion cell degeneration that has been investigated after geniculostriate damage. Given prior findings that some patients have preserved visual cortex activity for stimuli presented in their blind field, we tested whether that activity explains variability in retinal ganglion cell degeneration over and above visual ability. We prospectively studied 15 patients (four females, mean age = 63.7 years) with homonymous visual field defects secondary to stroke, 10 of whom were tested within the first two months after stroke. Each patient completed automated Humphrey visual field testing, retinotopic mapping with functional magnetic resonance imaging, and spectral-domain optical coherence tomography of the macula. There was a positive relation between ganglion cell complex (GCC) thickness in the blind field and early visual cortex activity for stimuli presented in the blind field. Furthermore, residual visual cortex activity for stimuli presented in the blind field soon after the stroke predicted the degree of retinal GCC thinning six months later. These findings indicate that retinal ganglion cell survival after ischaemic damage to the geniculostriate pathway is activity dependent.