Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?

The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and...

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Published inClinical cancer research Vol. 18; no. 4; pp. 920 - 922
Main Authors HUNT, Clayton R, GUPTA, Arun, HORIKOSHI, Nobuo, PANDITA, Tej K
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 15.02.2012
Subjects
Animals
Antineoplastic agents
Biological and medical sciences
Gene Deletion
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Prostatic Neoplasms - enzymology
Prostatic Neoplasms - genetics
PTEN Phosphohydrolase - genetics
Rad51 Recombinase - metabolism
Double stranded DNA
PTEN Gene
Repair
Homologous recombination
Tumor suppressor gene
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Summary:The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.ccr-11-3131