Biomarkers for EMT and MET in breast cancer: An update

Metastasis and recurrence are the leading cause of mortality due to breast cancer, but the underlying mechanisms are still poorly understood. Understanding the breast cancer metastasis mechanism is important for early diagnosis and treatment of breast cancer. The seeding and growth of breast cancer...

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Bibliographic Details
Published inOncology letters Vol. 12; no. 6; pp. 4869 - 4876
Main Authors Liu, Fei, Gu, Li-Na, Shan, Bao-En, Geng, Cui-Zhi, Sang, Mei-Xiang
Format Journal Article
LanguageEnglish
Published Greece D.A. Spandidos 01.12.2016
Spandidos Publications
Spandidos Publications UK Ltd
Subjects
biomarker
Biomarkers
Breast cancer
Care and treatment
Cell adhesion & migration
Cell division
Collagen
Development and progression
epithelial-mesenchymal transition
Gene expression
Genetic aspects
Health aspects
Kinases
mesenchymal-epithelial transition
Metastasis
microRNA
Prostate cancer
protein kinase
Proteins
Review
Rodents
Tumors
breast cancer
microRNA
epithelial-mesenchymal transition
biomarker
mesenchymal-epithelial transition
protein kinase
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Summary:Metastasis and recurrence are the leading cause of mortality due to breast cancer, but the underlying mechanisms are still poorly understood. Understanding the breast cancer metastasis mechanism is important for early diagnosis and treatment of breast cancer. The seeding and growth of breast cancer cells at sites distinct from the primary tumor is a complex and multistage process. Recently, it has been reported that the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET) are the main mechanisms for breast cancer metastasis. During EMT, carcinoma cells shed their differentiated epithelial characteristics, including cell-cell adhesion, polarity and lack of motility, and acquire mesenchymal traits, including motility and invasiveness. This review has summarized the studies of known EMT biomarkers in the context of breast cancer progression. These biomarkers include EMT-related genes, proteins, microRNAs and kinases. In general, the findings of these studies suggest that EMT markers are associated with the invasion and metastasis of breast cancer. Further studies on the link between EMT markers and breast cancer will contribute to identify biomarkers for predicting early breast cancer metastasis as well as to provide new ideas for the treatment of breast cancer.
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ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2016.5369